Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery.
Animals
Cell Line
Delayed-Action Preparations
/ chemistry
Doxorubicin
/ chemistry
Drug Carriers
/ chemistry
Drug Delivery Systems
/ methods
Gold
/ chemistry
Humans
Matrix Metalloproteinase 2
/ metabolism
Metal Nanoparticles
/ chemistry
Mice
Microscopy, Electron, Transmission
/ methods
Neoplasms
/ drug therapy
Porosity
RAW 264.7 Cells
Silicon Dioxide
/ chemistry
Enzyme-responsive nanocarriers
MMP-cleavable peptides
Stimuli-responsive nanocarriers
mesoporous silica nanoparticle
Journal
Journal of drug targeting
ISSN: 1029-2330
Titre abrégé: J Drug Target
Pays: England
ID NLM: 9312476
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
23
3
2019
medline:
19
8
2020
entrez:
23
3
2019
Statut:
ppublish
Résumé
Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of controlled drug delivery systems. In this study, a MSN-based nanocarrier was fabricated and gold nanoparticle (GNP)-biotin conjugates were successfully grafted onto the pore outlets of the prepared MSN. This bioconjugate served as a capping agent with a peptide-cleavable linker sensitive to matrix metalloproteinases (MMPs), which are overexpressed extracellular proteolytic enzymes in cancerous tissue. The prepared nanocarriers were fully characterised by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infra-red spectroscopy (FTIR), dynamic light scattering (DLS) and thermo gravimetric analysis (TGA).
Identifiants
pubmed: 30900473
doi: 10.1080/1061186X.2019.1599379
doi:
Substances chimiques
Delayed-Action Preparations
0
Drug Carriers
0
Gold
7440-57-5
Silicon Dioxide
7631-86-9
Doxorubicin
80168379AG
Matrix Metalloproteinase 2
EC 3.4.24.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM