Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links
RNA sequencing
albuminuria
blood pressure
genetics
genomics
human
next generation sequencing
rat
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 03 2019
22 03 2019
Historique:
received:
16
09
2018
accepted:
20
03
2019
pubmed:
23
3
2019
medline:
31
3
2020
entrez:
23
3
2019
Statut:
epublish
Résumé
Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next-generation sequencing, and compartment-specific RNA sequencing analysis in isolated glomeruli. This led to prioritization of transmembrane protein
Identifiants
pubmed: 30900988
doi: 10.7554/eLife.42068
pii: 42068
pmc: PMC6478434
doi:
pii:
Banques de données
GEO
['GSE102546']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG KR 1152-3-1
Pays : International
Organisme : Helmholtz-Gemeinschaft
ID : VH-NG-736
Pays : International
Organisme : European Commission
ID : WNT/CALCIUM IN HEART-322189
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU 2604/1-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : Project number 394046635 - SFB 1365
Pays : International
Organisme : Deutsche Hochdrckliga (DHL)
ID : Stiftungsprofessur Hypertensiologie
Pays : International
Informations de copyright
© 2019, Schulz et al.
Déclaration de conflit d'intérêts
AS, NM, Nv, AE, MS, AB, BP, AS, TL, AM, LH, AW, FR, WZ, Ed, MS, DP, MS, RK No competing interests declared
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