Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells.
Andrographis
/ chemistry
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Cell Line
Cyclophosphamide
/ administration & dosage
Dose-Response Relationship, Drug
Eleutherococcus
/ chemistry
Epirubicin
/ administration & dosage
Fluorouracil
/ administration & dosage
Humans
Neuroglia
/ drug effects
Neuroprotective Agents
/ administration & dosage
Plant Extracts
/ pharmacology
Rhodiola
/ chemistry
Chemobrain
Chemotherapy
Neurotoxicity
Phytotherapy
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
07
09
2018
revised:
02
11
2018
accepted:
05
11
2018
pubmed:
23
3
2019
medline:
20
8
2019
entrez:
23
3
2019
Statut:
ppublish
Résumé
Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation of more than 100 genes involved in the activation of neuronal death and inhibiting neurogenesis. Neuroprotective and cytoprotective activities of adaptogens rise the question about their possible impact on cytostatic effects of a chemotherapeutic combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC). The aim of this study was to assess the effects of selected adaptogenic herbal extracts, namely of andrographolide (AND), Herba Andrographidis (AP), Radix Eleutherococci (ES) genuine extracts, their fixed combination (AE), and the combination of three adaptogenic herbs, Rhodiola Radix, Shisandra Fructus and Eleutherococci Radix (RSE) on the cytotoxicity of a fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) on neuroglia cells. Cytotoxicity of FEC, adaptogenic extracts and their combination with FEC was tested on isolated T98G cells in a wide range of concentrations of all tested compounds. FEC reproducibly inhibited the proliferation of T98G cells by 50% at concentrations of 5 × 10 The neuroprotective effect of adaptogens did not attenuate the cytotoxic activity of FEC. Application of cytostatic drugs in combination with adaptogenic plant extracts likely have no impact in cytotoxic effect of FEC. Furthermore, AP and RSE potentiated the cytotoxic effects of FEC.
Sections du résumé
BACKGROUND
BACKGROUND
Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation of more than 100 genes involved in the activation of neuronal death and inhibiting neurogenesis. Neuroprotective and cytoprotective activities of adaptogens rise the question about their possible impact on cytostatic effects of a chemotherapeutic combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC).
AIM
OBJECTIVE
The aim of this study was to assess the effects of selected adaptogenic herbal extracts, namely of andrographolide (AND), Herba Andrographidis (AP), Radix Eleutherococci (ES) genuine extracts, their fixed combination (AE), and the combination of three adaptogenic herbs, Rhodiola Radix, Shisandra Fructus and Eleutherococci Radix (RSE) on the cytotoxicity of a fixed combination of 5-fluorouracil, epirubicin and cyclophosphamide (FEC) on neuroglia cells.
METHODS
METHODS
Cytotoxicity of FEC, adaptogenic extracts and their combination with FEC was tested on isolated T98G cells in a wide range of concentrations of all tested compounds.
RESULTS
RESULTS
FEC reproducibly inhibited the proliferation of T98G cells by 50% at concentrations of 5 × 10
CONCLUSION
CONCLUSIONS
The neuroprotective effect of adaptogens did not attenuate the cytotoxic activity of FEC. Application of cytostatic drugs in combination with adaptogenic plant extracts likely have no impact in cytotoxic effect of FEC. Furthermore, AP and RSE potentiated the cytotoxic effects of FEC.
Identifiants
pubmed: 30901664
pii: S0944-7113(18)30561-0
doi: 10.1016/j.phymed.2018.11.004
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Plant Extracts
0
Epirubicin
3Z8479ZZ5X
Cyclophosphamide
8N3DW7272P
Fluorouracil
U3P01618RT
perfosfamide
U880A4FUDA
Types de publication
Journal Article
Langues
eng
Pagination
152743Informations de copyright
Copyright © 2018. Published by Elsevier GmbH.