Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles.
Reovirus
bluetongue virus
double-stranded RNA
endoplasmic reticulum
rotavirus
viral factories
viral inclusions
viral nonstructural proteins
viral replication organelles
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
21 03 2019
21 03 2019
Historique:
received:
26
01
2019
revised:
17
03
2019
accepted:
19
03
2019
entrez:
24
3
2019
pubmed:
25
3
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation of cell-intrinsic defenses, and coordinate the release of progeny particles. Reoviruses are common pathogens of mammals that have been linked to celiac disease and show promise for oncolytic applications. These viruses form nonenveloped, double-shelled virions that contain ten segments of double-stranded RNA. Replication organelles in reovirus-infected cells are nucleated by viral nonstructural proteins µNS and σNS. Both proteins partition the endoplasmic reticulum to form the matrix of these structures. The resultant membranous webs likely serve to anchor viral RNA⁻protein complexes for the replication of the reovirus genome and the assembly of progeny virions. Ongoing studies of reovirus replication organelles will advance our knowledge about the strategies used by viruses to commandeer host biosynthetic pathways and may expose new targets for therapeutic intervention against diverse families of pathogenic viruses.
Identifiants
pubmed: 30901959
pii: v11030288
doi: 10.3390/v11030288
pmc: PMC6466366
pii:
doi:
Substances chimiques
RNA, Double-Stranded
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI032539
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI122563
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007281
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NIH HHS
ID : R01 AI032539
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Virol. 1972 Oct;10(4):698-706
pubmed: 4673489
J Virol. 2015 Jun;89(12):6184-95
pubmed: 25833056
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13154-9
pubmed: 12235365
mBio. 2013 Oct 22;4(5):e00801-13
pubmed: 24149513
Annu Rev Biochem. 2006;75:271-94
pubmed: 16756493
BMC Mol Biol. 2007 Jan 22;8:4
pubmed: 17241458
Curr Top Microbiol Immunol. 1990;162:89-118
pubmed: 2166649
J Virol. 1999 Mar;73(3):2016-26
pubmed: 9971782
Biol Cell. 2005 Feb;97(2):147-72
pubmed: 15656780
PLoS One. 2012;7(10):e47947
pubmed: 23110139
Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12015-E12023
pubmed: 30509975
PLoS One. 2017 Sep 7;12(9):e0184356
pubmed: 28880890
Subcell Biochem. 2013;68:417-40
pubmed: 23737060
J Biol Chem. 2007 Feb 23;282(8):5888-98
pubmed: 17182608
J Virol. 2014 Jan;88(2):786-98
pubmed: 24198401
J Virol. 2012 Jan;86(2):1079-89
pubmed: 22090113
Virology. 1971 Mar;43(3):569-78
pubmed: 4107549
J Virol. 2010 Jul;84(13):6782-98
pubmed: 20335253
Cell Microbiol. 2013 Jan;15(1):24-34
pubmed: 22978691
Curr Opin Microbiol. 2012 Aug;15(4):519-24
pubmed: 22621853
J Virol Methods. 1996 Jan;56(1):67-75
pubmed: 8690769
J Virol. 2018 Jul 17;92(15):
pubmed: 29769336
Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16304-9
pubmed: 15520389
J Biol Chem. 1998 Jun 12;273(24):15227-33
pubmed: 9614137
Virology. 1989 Nov;173(1):21-34
pubmed: 2554570
Mol Cell Biol. 1993 Apr;13(4):2478-85
pubmed: 8096061
mBio. 2014 Sep 16;5(5):e01463-14
pubmed: 25227463
J Virol. 1992 Sep;66(9):5347-56
pubmed: 1501278
Proc Natl Acad Sci U S A. 1980 Jan;77(1):152-6
pubmed: 6244540
Virus Res. 2014 Mar;182:5-20
pubmed: 24370866
J Virol. 1997 Jul;71(7):4921-8
pubmed: 9188554
Trends Microbiol. 2014 Dec;22(12):715-24
pubmed: 25245455
J Virol. 2017 Oct 27;91(22):
pubmed: 28878073
Virology. 2004 Mar 15;320(2):276-90
pubmed: 15016550
PLoS Biol. 2008 Sep 16;6(9):e226
pubmed: 18798692
Cell Mol Life Sci. 2005 Mar;62(6):670-84
pubmed: 15770419
J Virol. 2004 Feb;78(4):1882-92
pubmed: 14747553
Cell Microbiol. 2017 Dec;19(12):
pubmed: 28672089
J Virol. 2002 Apr;76(7):3461-70
pubmed: 11884570
Virology. 1962 Jun;17:342-55
pubmed: 14491769
Nature. 2009 Aug 20;460(7258):978-83
pubmed: 19633650
J Virol. 2010 Mar;84(5):2522-32
pubmed: 20032187
J Gen Virol. 2007 Oct;88(Pt 10):2800-10
pubmed: 17872534
J Virol. 1991 Apr;65(4):1960-7
pubmed: 2002551
Cell. 2002 Nov 27;111(5):733-45
pubmed: 12464184
J Virol. 2002 May;76(9):4483-96
pubmed: 11932414
EMBO J. 2002 Jan 15;21(1-2):1-11
pubmed: 11782420
J Virol. 2010 Jan;84(2):867-82
pubmed: 19889754
J Virol. 2011 Nov;85(22):11964-71
pubmed: 21900156
mBio. 2018 Aug 7;9(4):
pubmed: 30087167
Annu Rev Biochem. 2015;84:791-811
pubmed: 25580528
Curr Opin Virol. 2016 Jun;18:20-6
pubmed: 26985879
Cell Host Microbe. 2009 Apr 23;5(4):365-75
pubmed: 19380115
Nat Rev Microbiol. 2008 May;6(5):363-74
pubmed: 18414501
Curr Top Microbiol Immunol. 2006;309:67-85
pubmed: 16909897
Nat Commun. 2017 Nov 9;8(1):1396
pubmed: 29123131
Cell. 1992 Oct 30;71(3):479-88
pubmed: 1423608
mBio. 2014 Feb 18;5(1):
pubmed: 24549844
J Virol. 2002 Aug;76(16):8285-97
pubmed: 12134034
J Virol. 2011 Mar;85(6):2781-92
pubmed: 21228236
J Virol. 2008 Nov;82(21):10600-12
pubmed: 18753209
Virology. 1965 Feb;25:193-211
pubmed: 14297208
J Gen Virol. 2010 Jul;91(Pt 7):1782-93
pubmed: 20200190
Biol Cell. 2011 Sep;103(9):405-20
pubmed: 21812762
Nat Cell Biol. 2012 Jun 24;14(7):707-16
pubmed: 22729086
Viruses. 2016 Jun 07;8(6):
pubmed: 27338443
Proc Natl Acad Sci U S A. 1975 Feb;72(2):742-5
pubmed: 1054852
J Virol. 2005 Feb;79(4):2240-50
pubmed: 15681426
Trends Cell Biol. 2004 Nov;14(11):598-604
pubmed: 15519848
J Mol Biol. 2004 Aug 6;341(2):361-74
pubmed: 15276829
Nat Struct Biol. 2003 Dec;10(12):1011-8
pubmed: 14608373
J Virol. 1997 Nov;71(11):8268-78
pubmed: 9343179
Virology. 1992 Apr;187(2):760-76
pubmed: 1546466
World J Virol. 2013 May 12;2(2):32-48
pubmed: 24175228
Structure. 2012 May 9;20(5):759-66
pubmed: 22579245
J Virol. 1987 Aug;61(8):2472-9
pubmed: 3298685
Curr Opin Virol. 2016 Aug;19:11-5
pubmed: 27341619
Virology. 1982 Jul 30;120(2):399-411
pubmed: 7201720
Virol J. 2007 Jan 15;4:7
pubmed: 17224050
Viruses. 2018 Nov 27;10(12):
pubmed: 30486370
Curr Top Microbiol Immunol. 2006;309:117-67
pubmed: 16909899
Nat Microbiol. 2018 Apr;3(4):481-493
pubmed: 29531365
J Virol. 2017 Oct 13;91(21):
pubmed: 28794026
J Cell Biol. 1973 May;57(2):551-65
pubmed: 4121290
J Virol. 2018 Jul 17;92(15):
pubmed: 29769334
Viruses. 2014 Aug 21;6(8):3250-70
pubmed: 25196482
Cell Rep. 2015 Feb 3;10(4):600-15
pubmed: 25640182
J Gen Virol. 1990 Sep;71 ( Pt 9):2073-83
pubmed: 2170574
J Virol. 1987 Aug;61(8):2351-61
pubmed: 2885424
Proc Natl Acad Sci U S A. 1963 Aug;50:268-75
pubmed: 14060643
PLoS Pathog. 2014 Oct 16;10(10):e1004388
pubmed: 25329172
J Virol. 2001 Feb;75(3):1459-75
pubmed: 11152519
Cell. 1992 Jun 12;69(6):1043-50
pubmed: 1351421
J Virol. 2007 Aug;81(15):8192-200
pubmed: 17522227
Nat Rev Microbiol. 2012 Jan 23;10(3):165-77
pubmed: 22266782
Sci Rep. 2017 Sep 7;7(1):10873
pubmed: 28883463
Cell Host Microbe. 2014 Nov 12;16(5):677-90
pubmed: 25525797
Curr Top Microbiol Immunol. 2006;309:221-44
pubmed: 16909901
J Virol. 2010 May;84(9):4289-301
pubmed: 20181708
J Virol. 2003 May;77(10):5948-63
pubmed: 12719587
Virology. 1970 Jul;41(3):564-6
pubmed: 4912824
J Virol. 2006 Jun;80(12):5927-40
pubmed: 16731931
PLoS One. 2014 Apr 15;9(4):e95197
pubmed: 24736649
Virology. 1997 May 26;232(1):62-73
pubmed: 9185589
Nucleic Acids Res. 2015 Aug 18;43(14):7044-57
pubmed: 26109354
J Biol Chem. 2002 Jul 5;277(27):24609-17
pubmed: 11986312
J Biol Chem. 2016 Jul 8;291(28):14566-74
pubmed: 27226558
PLoS Pathog. 2013;9(8):e1003513
pubmed: 23935497
J Gen Virol. 2013 Jul;94(Pt 7):1576-1586
pubmed: 23515026
J Virol. 2010 Oct;84(20):10438-47
pubmed: 20686019
J Gen Virol. 1993 Mar;74 ( Pt 3):525-30
pubmed: 8383185
Mol Ther. 2012 Sep;20(9):1810-20
pubmed: 22713696
J Virol. 2012 Oct;86(20):10979-87
pubmed: 22837214
Virology. 2018 May;518:77-86
pubmed: 29455064
Virology. 1987 Sep;160(1):220-6
pubmed: 2820130
Virol J. 2004 Sep 23;1:6
pubmed: 15507160
EMBO J. 1996 Sep 2;15(17):4469-76
pubmed: 8887538
J Virol. 2003 Apr;77(8):4566-76
pubmed: 12663763
Virology. 1970 Jul;41(3):501-18
pubmed: 5463865
Curr Top Microbiol Immunol. 2006;309:169-87
pubmed: 16909900
Structure. 2012 May 9;20(5):814-25
pubmed: 22503819
Virology. 1962 Jul;17:441-54
pubmed: 13900037
J Gen Virol. 1999 Feb;80 ( Pt 2):333-339
pubmed: 10073692
J Gen Virol. 2010 Sep;91(Pt 9):2230-7
pubmed: 20484561
J Mol Biol. 1968 Aug 28;36(1):107-23
pubmed: 5760535