Fibroblast growth factors in skeletal development.
Chondrocyte
Chondrodysplasia
Craniosynostosis
Endochondral ossification
Fibroblast growth factor receptors
Fibroblast growth factors
Heparan sulfate proteoglycans
Intracellular signaling
Intramembranous ossification
Osteoblast
Receptor tyrosine kinase
Journal
Current topics in developmental biology
ISSN: 1557-8933
Titre abrégé: Curr Top Dev Biol
Pays: United States
ID NLM: 0163114
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
24
3
2019
pubmed:
25
3
2019
medline:
7
3
2020
Statut:
ppublish
Résumé
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are expressed throughout all stages of skeletal development. In the limb bud and in cranial mesenchyme, FGF signaling is important for formation of mesenchymal condensations that give rise to bone. Once skeletal elements are initiated and patterned, FGFs regulate both endochondral and intramembranous ossification programs. In this chapter, we review functions of the FGF signaling pathway during these critical stages of skeletogenesis, and explore skeletal malformations in humans that are caused by mutations in FGF signaling molecules.
Identifiants
pubmed: 30902253
pii: S0070-2153(18)30099-1
doi: 10.1016/bs.ctdb.2018.11.020
pii:
doi:
Substances chimiques
Receptors, Fibroblast Growth Factor
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-234Subventions
Organisme : NICHD NIH HHS
ID : R01 HD049808
Pays : United States
Informations de copyright
© 2019 Elsevier Inc. All rights reserved.