Innate lymphoid cells: A potential link between microbiota and immune responses against cancer.
Anti-tumor immunity
Cancer
Commensal microbiota
ILCs
Immunotherapy
NK cells
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
01
2019
revised:
10
03
2019
accepted:
14
03
2019
pubmed:
25
3
2019
medline:
4
4
2020
entrez:
24
3
2019
Statut:
ppublish
Résumé
The adaptive immune system plays a crucial role in anti-tumor surveillance. Enhancement of T cell responses through checkpoint blockade has become a major therapeutic avenue of intervention for several tumors. Because it shapes immune responses and regulates their amplitude and duration, the microbiota has a substantial impact on anti-tumor immunity. Innate lymphoid cells (ILCs) comprise a heterogeneous population of lymphocytes devoid of antigen-specific receptors that mirror T helper cells in their ability to secrete cytokines that activate immune responses. Ongoing studies suggest that ILCs contribute to anti-tumor responses. Moreover, since ILCs are present at barrier surfaces, they are stimulated by the microbiota and, reciprocally, influence the composition of the microbiota by regulating the surface barrier microenvironment. Thus, ILC-microbiota cross-talk may in part underpin the effects of the microbiota on anti-tumor responses. In this article, we review current evidence linking ILCs to cancer and discuss the potential impact of ILC-microbiota cross-talk in anti-tumor immune responses.
Identifiants
pubmed: 30902413
pii: S1044-5323(18)30117-9
doi: 10.1016/j.smim.2019.03.003
pmc: PMC6731134
mid: NIHMS1525129
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101271Subventions
Organisme : NIAID NIH HHS
ID : R01 AI134236
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025884
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095542
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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