[Assessment of muscular toxicity due to chemotherapy by cardio-pulmonary exercise testing].
Évaluation de la toxicité musculaire de la chimiothérapie lors d’une épreuve fonctionnelle à l'exercice.
Aged
Antineoplastic Agents
/ adverse effects
Carcinoma, Non-Small-Cell Lung
/ diagnosis
Cardiorespiratory Fitness
/ physiology
Chemotherapy, Adjuvant
/ adverse effects
Exercise Test
/ adverse effects
Exercise Tolerance
/ drug effects
Humans
Lung Neoplasms
/ diagnosis
Male
Muscular Diseases
/ chemically induced
Oxygen Consumption
/ drug effects
Pneumonectomy
/ adverse effects
Aerobic capacity
Aptitude aérobie
Arterio-venous oxygen difference
Cancer
Différence artérioveineuse en oxygène
Limitation périphérique musculaire
Muscular limitation
Journal
Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
02
06
2017
accepted:
02
11
2018
pubmed:
25
3
2019
medline:
27
8
2019
entrez:
24
3
2019
Statut:
ppublish
Résumé
Cardio-pulmonary exercise testing (CPET) is frequently used to assess aerobic capacity, to evaluate respiratory tolerance and to provide prognostic information. Therefore, CPET is often incorporated in the preoperative assessment of cancer patients. This clinical case report presents the preoperative assessment of a patient before thoracic surgery, in whom an important decrease of aerobic capacity was noted, possibly because of muscular toxicity linked to chemotherapy. This clinical case concerns a fit, 66-year-old man with a large cell carcinoma of the bronchus. He had received 2 cycles of adjuvant chemotherapy. Subsequently, a left pneumonectomy had been proposed and preoperative assessment performed. CPET showed no further increase in oxygen uptake after the first ventilatory threshold, in spite of increases in carbon dioxide output, minute ventilation and heart rate. Moreover, maximal oxygen uptake was low and there was a decrease of oxygen pulse at maximal effort. We suggest that the limitation of effort was due to a limitation of muscular oxygen extraction, which could be explained by possible muscular toxicity due to chemotherapy.
Identifiants
pubmed: 30902442
pii: S0761-8425(18)31008-8
doi: 10.1016/j.rmr.2018.11.006
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Case Reports
Journal Article
Langues
fre
Pagination
364-368Informations de copyright
Copyright © 2018 SPLF. Published by Elsevier Masson SAS. All rights reserved.