Genetic Control of Gonadal Sex Determination and Development.
Sertoli cells
cell fate decision
differentiation
epigenetic regulation
gene expression
gonadal sex determination
granulosa cells
lineage specification
ovary
progenitors
supporting cells
testis
transcriptomics
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
12
2018
revised:
15
02
2019
accepted:
23
02
2019
pubmed:
25
3
2019
medline:
1
7
2020
entrez:
24
3
2019
Statut:
ppublish
Résumé
Sex determination is the process by which the bipotential gonads develop as either testes or ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model for the study of cell fate specification and how distinct cell populations diverge from multipotent progenitors. This review focuses on recent advances in our understanding of the genetic programs and epigenetic mechanisms that regulate gonadal sex determination and the regulation of cell fate commitment in the bipotential gonads. We rely primarily on mouse data to illuminate the complex and dynamic genetic programs controlling cell fate decision and sex-specific cell differentiation during gonadal formation and gonadal sex determination.
Identifiants
pubmed: 30902461
pii: S0168-9525(19)30033-2
doi: 10.1016/j.tig.2019.02.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
346-358Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.