Sample Treatments That Solve Low Endotoxin Recovery Issues.

Biological Products / chemistry Chelating Agents / chemistry Detergents / chemistry Drug Contamination / prevention & control Endotoxins / analysis Equipment and Supplies / standards Limulus Test / methods Magnesium / chemistry Serum Albumin, Human
Bacterial endotoxins test Endotoxin Limulus amebocyte lysate Lipopolysaccharide Low endotoxin recovery (LER) Magnesium dilution

Journal

PDA journal of pharmaceutical science and technology
ISSN: 1948-2124
Titre abrégé: PDA J Pharm Sci Technol
Pays: United States
ID NLM: 9439538

Informations de publication

Date de publication:
Historique:
pubmed: 25 3 2019
medline: 6 6 2020
entrez: 24 3 2019
Statut: ppublish

Résumé

Dilution of samples with water (water dilution method) was not appropriate for measuring the endotoxin activity in solutions containing chelating agents and detergents-typical formulations showing low endotoxin recovery (LER). Dilution of the samples with 2 mM magnesium solution (magnesium dilution method) or addition of the samples directly to the

Identifiants

DOI: 10.5731/pdajpst.2018.009464 PMID: 30902837
pubmed: 30902837
pii: pdajpst.2018.009464
doi: 10.5731/pdajpst.2018.009464
doi:

Substances chimiques

Biological Products 0
Chelating Agents 0
Detergents 0
Endotoxins 0
Magnesium I38ZP9992A
Serum Albumin, Human ZIF514RVZR

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

433-442

Informations de copyright

© PDA, Inc. 2019.

Auteurs

Masakazu Tsuchiya (M)

Charles River Microbial Solutions, 1023 Wappoo Road, Suite 43B, Charleston, SC 29407.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents séquestrants › Chélateurs › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits domestiques › Détergents › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Contamination de médicament › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Équipement et fournitures › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Techniques bactériologiques › Test LAL › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Sample Treatments That Solve Low Endotoxin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérum-albumine humaine › Sample Treatments That Solve Low Endotoxin...