Anti-Nogo-A Antibodies As a Potential Causal Therapy for Lower Urinary Tract Dysfunction after Spinal Cord Injury.
CRF
Nogo-A
neuro-urology
neurogenic lower urinary tract dysfunction
spinal cord injury
urodynamics
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
received:
17
12
2018
accepted:
06
02
2019
pubmed:
25
3
2019
medline:
13
6
2020
entrez:
24
3
2019
Statut:
ppublish
Résumé
Loss of bladder control is common after spinal cord injury (SCI) and no causal therapies are available. Here we investigated whether function-blocking antibodies against the nerve-fiber growth inhibitory protein Nogo-A applied to rats with severe SCI could prevent development of neurogenic lower urinary tract dysfunction. Bladder function of rats with SCI was repeatedly assessed by urodynamic examination in fully awake animals. Four weeks after SCI, detrusor sphincter dyssynergia had developed in all untreated or control antibody-infused animals. In contrast, 2 weeks of intrathecal anti-Nogo-A antibody treatment led to significantly reduced aberrant maximum detrusor pressure during voiding and a reduction of the abnormal EMG high-frequency activity in the external urethral sphincter. Anatomically, we found higher densities of fibers originating from the pontine micturition center in the lumbosacral gray matter in the anti-Nogo-A antibody-treated animals, as well as a reduced number of inhibitory interneurons in lamina X. These results suggest that anti-Nogo-A therapy could also have positive effects on bladder function clinically.
Identifiants
pubmed: 30902870
pii: JNEUROSCI.3155-18.2019
doi: 10.1523/JNEUROSCI.3155-18.2019
pmc: PMC6529870
doi:
Substances chimiques
Antibodies
0
Nogo Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4066-4076Informations de copyright
Copyright © 2019 the authors.
Références
Neurosci Lett. 2000 Mar 17;282(1-2):29-32
pubmed: 10713388
Urology. 2000 Oct 1;56(4):565-8
pubmed: 11018603
J Comp Neurol. 2001 Jan 22;429(4):631-7
pubmed: 11135240
Brain Res. 2001 Jun 8;903(1-2):33-44
pubmed: 11382385
Neurourol Urodyn. 2002;21(2):167-78
pubmed: 11857671
J Neurosci. 2003 Jul 2;23(13):5393-406
pubmed: 12843238
Exp Neurol. 2003 Sep;183(1):232-40
pubmed: 12957506
Nat Neurosci. 2004 Mar;7(3):269-77
pubmed: 14966523
Exp Neurol. 2004 Jun;187(2):445-54
pubmed: 15144870
J Urol. 2005 Jan;173(1):314-7
pubmed: 15592103
Cell Tissue Res. 2005 Dec;322(3):339-52
pubmed: 16001267
Ann Neurol. 2005 Nov;58(5):706-19
pubmed: 16173073
Nat Med. 2006 Jul;12(7):790-2
pubmed: 16819551
Neurourol Urodyn. 2007;26(2):228-33
pubmed: 16998859
J Urol. 2008 Mar;179(3):1178-83
pubmed: 18206170
Eur J Neurosci. 2008 Jan;27(2):326-33
pubmed: 18215231
Nat Rev Neurosci. 2008 Jun;9(6):453-66
pubmed: 18490916
Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R336-42
pubmed: 18495826
Nat Rev Neurosci. 2010 Dec;11(12):799-811
pubmed: 21045861
Anat Cell Biol. 2011 Mar;44(1):60-8
pubmed: 21519550
J Auton Nerv Syst. 1990 Jul;30 Suppl:S71-7
pubmed: 2212495
J Neurotrauma. 2012 May 20;29(8):1548-55
pubmed: 22320160
BJU Int. 2012 Apr;109 Suppl 3:31-4
pubmed: 22458490
J Appl Physiol (1985). 1990 Mar;68(3):1177-85
pubmed: 2341343
Brain. 2014 Mar;137(Pt 3):739-56
pubmed: 24355710
Curr Opin Neurobiol. 2014 Aug;27:53-60
pubmed: 24632308
Science. 2014 Jun 13;344(6189):1250-5
pubmed: 24926013
J Neurosci. 2014 Oct 1;34(40):13399-410
pubmed: 25274818
Compr Physiol. 2015 Jan;5(1):327-96
pubmed: 25589273
BJU Int. 2015 Apr;115 Suppl 6:8-15
pubmed: 25597776
BJU Int. 2015 Apr;115 Suppl 6:33-8
pubmed: 25891318
Lancet Neurol. 2015 Jul;14(7):720-32
pubmed: 26067125
Eur Urol. 2016 Feb;69(2):324-33
pubmed: 26304502
Nat Protoc. 2017 Jan;12(1):104-131
pubmed: 27977023
PLoS One. 2017 Mar 10;12(3):e0173452
pubmed: 28282410
J Comp Neurol. 2017 Jul 1;525(10):2287-2309
pubmed: 28340519
J Urol. 2018 Jun;199(6):1565-1570
pubmed: 29352989
J Vis Exp. 2018 Jan 30;(131):
pubmed: 29443095
Neurorehabil Neural Repair. 2018 Jun;32(6-7):578-589
pubmed: 29869587
Nat Neurosci. 2018 Sep;21(9):1229-1238
pubmed: 30104734
Peptides. 1985 Mar-Apr;6(2):307-18
pubmed: 3875838
J Physiol. 1972 Oct;226(2):289-309
pubmed: 4508051
J Physiol. 1968 Jun;196(3):563-77
pubmed: 5664233
J Comp Neurol. 1984 Jun 20;226(2):238-45
pubmed: 6736301
J Neurotrauma. 1995 Feb;12(1):1-21
pubmed: 7783230
Neuroscience. 1994 Sep;62(1):125-43
pubmed: 7816195
J Comp Neurol. 1997 Dec 29;389(4):584-602
pubmed: 9421141