Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Animals Anti-Bacterial Agents / blood Cephalosporins / blood Mice Molecular Structure Structure-Activity Relationship

Journal

The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115

Informations de publication

Date de publication:
06 2019
Historique:
received: 10 12 2018
accepted: 22 02 2019
revised: 18 02 2019
pubmed: 25 3 2019
medline: 5 11 2019
entrez: 24 3 2019
Statut: ppublish

Résumé

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

Identifiants

DOI: 10.1038/s41429-019-0167-y PMID: 30903100 PMC: PMC7255492
pubmed: 30903100
doi: 10.1038/s41429-019-0167-y
pii: 10.1038/s41429-019-0167-y
pmc: PMC7255492
mid: NIHMS1588225
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cephalosporins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

469-475

Subventions

Organisme : NIH HHS
ID : S10 OD023524
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111143
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG005031
Pays : United States

Références

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pubmed: 27144688

Auteurs

Matthew Zimmerman (M)

Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.

Stacey L McDonald (SL)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Hsin-Pin Ho-Liang (HP)

Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA.

Patrick Porubsky (P)

Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.

Quyen Nguyen (Q)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.

Cameron W Pharr (CW)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Andrew J Perkowski (AJ)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Robert Smith (R)

Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.

Frank J Schoenen (FJ)

Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA.

Ben S Gold (BS)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.

David Zhang (D)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.

Carl F Nathan (CF)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA.

Véronique Dartois (V)

Public Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ, 07013, USA. veronique.dartois@rutgers.edu.

Jeffrey Aubé (J)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. jaube@unc.edu.
Specialized Chemistry Center, University of Kansas, Lawrence, KS, 66045, USA. jaube@unc.edu.
ORCID: 0000-0003-1049-5767

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effect of C-2 substitution on the stability of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Effect of C-2 substitution on the stability of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Effect of C-2 substitution on the stability of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Effect of C-2 substitution on the stability of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Effect of C-2 substitution on the stability of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Effect of C-2 substitution on the stability of...