Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality.
Adolescent
Adult
Aged
Capsule Endoscopy
/ statistics & numerical data
Cytomegalovirus Infections
/ diagnosis
Female
Gastrointestinal Diseases
/ diagnosis
Graft vs Host Disease
/ diagnosis
Hematopoietic Stem Cell Transplantation
/ mortality
Humans
Leukemia
/ therapy
Lymphoma
/ therapy
Middle Aged
Neoplasms, Plasma Cell
/ therapy
Predictive Value of Tests
Retrospective Studies
Young Adult
Capsule endoscopy
Graft-versus-host disease
Transplant-related mortality
Journal
Digestion
ISSN: 1421-9867
Titre abrégé: Digestion
Pays: Switzerland
ID NLM: 0150472
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
10
2018
accepted:
11
02
2019
pubmed:
25
3
2019
medline:
1
12
2020
entrez:
25
3
2019
Statut:
ppublish
Résumé
Allogenic hematopoietic stem cell transplantation (allo-SCT) is a curative therapy for hematological malignancies, but transplant-related mortality (TRM) remains a concern. This study aimed to determine the efficacy of capsule endoscopy (CE) by evaluating the correlation between inflammatory findings on CE and TRM. The data of patients after allo-SCT were retrospectively collected. The association between findings on CE and TRM at 100 days from the CE was evaluated. Of the 94 patients included in the study, 47 showed inflammatory findings on CE. The findings were diagnosed as graft-versus-host disease (GVHD; n = 17), cytomegalovirus (CMV) infection (n = 14), and GVHD with CMV infection (n = 16). Of the 47 patients, 13 (28%) had TRM. Endoscopic diagnoses of these TRM cases were GVHD (n = 4), CMV infection (n = 0), and GVHD with CMV infection (n = 9). In contrast, in the remaining 47 patients who showed no inflammatory findings on CE, 2 patients (4%) had TRM. The proportion of TRM was higher in patients with inflammatory findings than in those without it (28 vs. 4%, p < 0.01). CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Allogenic hematopoietic stem cell transplantation (allo-SCT) is a curative therapy for hematological malignancies, but transplant-related mortality (TRM) remains a concern. This study aimed to determine the efficacy of capsule endoscopy (CE) by evaluating the correlation between inflammatory findings on CE and TRM.
METHODS
METHODS
The data of patients after allo-SCT were retrospectively collected. The association between findings on CE and TRM at 100 days from the CE was evaluated.
RESULTS
RESULTS
Of the 94 patients included in the study, 47 showed inflammatory findings on CE. The findings were diagnosed as graft-versus-host disease (GVHD; n = 17), cytomegalovirus (CMV) infection (n = 14), and GVHD with CMV infection (n = 16). Of the 47 patients, 13 (28%) had TRM. Endoscopic diagnoses of these TRM cases were GVHD (n = 4), CMV infection (n = 0), and GVHD with CMV infection (n = 9). In contrast, in the remaining 47 patients who showed no inflammatory findings on CE, 2 patients (4%) had TRM. The proportion of TRM was higher in patients with inflammatory findings than in those without it (28 vs. 4%, p < 0.01).
CONCLUSIONS
CONCLUSIONS
CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT.
Identifiants
pubmed: 30904916
pii: 000498846
doi: 10.1159/000498846
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
198-207Informations de copyright
© 2019 S. Karger AG, Basel.