Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood.
Brain-derived neurotrophic factor
Depression
Fetal cord blood
Neurodevelopment
Pregnancy
Journal
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
ISSN: 1738-1088
Titre abrégé: Clin Psychopharmacol Neurosci
Pays: Korea (South)
ID NLM: 101207332
Informations de publication
Date de publication:
31 May 2019
31 May 2019
Historique:
received:
12
04
2016
revised:
27
05
2016
accepted:
16
06
2016
entrez:
26
3
2019
pubmed:
25
3
2019
medline:
25
3
2019
Statut:
ppublish
Résumé
: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. : A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. : The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didnt find any correlation between the umbilical cord blood BDNF levels and BDI scores. : The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.
Identifiants
pubmed: 30905131
pii: cpn.2019.17.2.308
doi: 10.9758/cpn.2019.17.2.308
pmc: PMC6478092
doi:
Types de publication
Journal Article
Langues
eng
Pagination
308-313Références
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