Branched-Chain and Aromatic Amino Acids Are Associated With Insulin Resistance During Pubertal Development in Girls.

Adolescent Amino Acids, Aromatic / blood Amino Acids, Branched-Chain / blood Blood Glucose / metabolism Body Mass Index Child Female Humans Insulin / blood Insulin Resistance Longitudinal Studies Menarche / metabolism
Amino acids Females Insulin resistance Puberty

Journal

The Journal of adolescent health : official publication of the Society for Adolescent Medicine
ISSN: 1879-1972
Titre abrégé: J Adolesc Health
Pays: United States
ID NLM: 9102136

Informations de publication

Date de publication:
09 2019
Historique:
received: 19 10 2018
revised: 24 01 2019
accepted: 30 01 2019
pubmed: 25 3 2019
medline: 12 9 2020
entrez: 26 3 2019
Statut: ppublish

Résumé

Cross-sectional studies in children show branched-chain and aromatic amino acids are associated with insulin resistance, but whether these associations persist from childhood to adulthood is not known. This study aimed to assess whether circulating amino acids associate with insulin resistance during pubertal development. This was a 7.5-year longitudinal study from childhood to early adulthood. A total of 396 nondiabetic Finnish girls aged 11.2 ± .8 years at baseline participated in the study which was conducted at the Health Science Laboratory, University of Jyväskylä. Serum concentrations of glucose and insulin were determined by enzymatic photometric methods and amino acids by nuclear magnetic resonance spectroscopy. Insulin resistance was determined by the homeostatic model assessment of insulin resistance (HOMA-IR). All amino acids were positively associated with HOMA-IR both before and after menarche (p < .05 for all), except for histidine. Branched-chain amino acids and aromatic amino acids showed the strongest associations, the magnitude of correlation coefficients being similar before and after menarche (R Branched-chain amino acids and aromatic amino acids associate with insulin resistance during pubertal development, independent of adiposity. Further studies are needed to determine whether changes in amino acid metabolism link pubertal hyperinsulinemia to accelerated physiological growth and/or heightened cardiometabolic risk later in life.

Identifiants

DOI: 10.1016/j.jadohealth.2019.01.030 PMID: 30905504
pubmed: 30905504
pii: S1054-139X(19)30072-2
doi: 10.1016/j.jadohealth.2019.01.030
pii:
doi:

Substances chimiques

Amino Acids, Aromatic 0
Amino Acids, Branched-Chain 0
Blood Glucose 0
Insulin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

337-343

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Auteurs

Xiaobo Zhang (X)

The Key Laboratory of Systems Biomedicine, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China.

Xiaowei Ojanen (X)

The Key Laboratory of Systems Biomedicine, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Haihui Zhuang (H)

The Key Laboratory of Systems Biomedicine, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China.

Na Wu (N)

The Key Laboratory of Systems Biomedicine, Ministry of Education, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China; Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China.

Sulin Cheng (S)

Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Faculty of Sport Sciences, University of Jyväskylä, Jyväskylä, Finland; Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: shulin.cheng@jyu.fi.

Petri Wiklund (P)

Exercise, Health and Technology Center, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: p.wiklund@imperial.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés à chaine ramifiée › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Branched-Chain and Aromatic Amino Acids Are...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › Ménarche › Branched-Chain and Aromatic Amino Acids Are...