Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization.

Animals Humans Lipid Droplets / metabolism Lipid Metabolism Mitochondria / metabolism Mitochondrial Dynamics
adipose tissue fat fatty acid oxidation lipid lipid droplet mitochondria obesity peridroplet mitochondria triacylglyceride triacylglycerol

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
02 04 2019
Historique:
received: 23 09 2018
revised: 21 01 2019
accepted: 21 02 2019
pubmed: 25 3 2019
medline: 2 6 2020
entrez: 26 3 2019
Statut: ppublish

Résumé

The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a central parameter determining mitochondrial fusion, adherence to LDs provides a mechanism by which peridroplet mitochondria (PDM) remain segregated from cytoplasmic mitochondria (CM). The existence of metabolically distinct subpopulations provides an explanation for the capacity of mitochondria within the individual cell to be involved simultaneously in fatty acid oxidation and LD formation. The mechanisms that deploy mitochondria to the LD and the dysfunctions that result from unbalanced proportions of PDM and CM remain to be explored. Understanding the roles and regulation of mitochondrial tethering to LDs offers new points of intervention in metabolic diseases.

Identifiants

DOI: 10.1016/j.cmet.2019.02.011 PMID: 30905670 PMC: PMC6476311
pubmed: 30905670
pii: S1550-4131(19)30075-0
doi: 10.1016/j.cmet.2019.02.011
pmc: PMC6476311
mid: NIHMS1524179
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

827-835

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK056690
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099618
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007201
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Ilan Y Benador (IY)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Michaela Veliova (M)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Marc Liesa (M)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular Biology Institute, Los Angeles, CA, USA. Electronic address: mliesa@mednet.ucla.edu.

Orian S Shirihai (OS)

Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. Electronic address: oshirihai@mednet.ucla.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondria Bound to Lipid Droplets: Where...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mitochondria Bound to Lipid Droplets: Where...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Gouttelettes lipidiques › Mitochondria Bound to Lipid Droplets: Where...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Mitochondria Bound to Lipid Droplets: Where...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondria Bound to Lipid Droplets: Where...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dynamique mitochondriale › Mitochondria Bound to Lipid Droplets: Where...