Neuro-restorative effect of sertoli cell transplants in a rat model of amyloid beta toxicity.
Alzheimer’s
Hippocampus
Neuroprotection
Sertoli cells
Transplantation
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
23 07 2019
23 07 2019
Historique:
received:
20
11
2018
revised:
14
03
2019
accepted:
15
03
2019
pubmed:
25
3
2019
medline:
9
6
2020
entrez:
26
3
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a degenerative nerve disease which adversely affects memory and learning skills. Currently, there is no disease-modifying therapeutic approach for AD. However, a growing body of literature suggests cell based therapies as a promising remedy for neurological disorders. Among the potential cell sources, testis- derived Sertoli cells (SCs) appear to be an attractive choice due to their immune-privileged capacities. Herein, we investigated the neuro-restorative/protective effects of SC transplants in a rat model of amyloid beta toxicity. To this end, GATA-4 and vimentin positive SCs were transplanted into rats with amyloid beta induced hippocampal lesions. According to our in vivo results, implanted SCs survived, exhibited reduction in both apoptosis as well as astrocytic migration. Additionally, transplantation of SCs restored hippocampus dependent memory and learning, along with the recovery of long-term synaptic plasticity. Taken together, these data indicate that SCs are a valuable source for cell-based therapies particularly aimed at AD.
Identifiants
pubmed: 30905711
pii: S0166-4328(18)31633-4
doi: 10.1016/j.bbr.2019.03.030
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Vimentin
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-165Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.