Developmental functioning and symptom severity influence age of diagnosis in Canadian preschool children with autism.

autism spectrum disorder cognitive development early diagnosis language development

Journal

Paediatrics & child health
ISSN: 1205-7088
Titre abrégé: Paediatr Child Health
Pays: England
ID NLM: 9815960

Informations de publication

Date de publication:
Feb 2019
Historique:
entrez: 26 3 2019
pubmed: 25 3 2019
medline: 25 3 2019
Statut: ppublish

Résumé

Early diagnosis of autism spectrum disorder (ASD) is essential in most Canadian jurisdictions to access interventions that improve long-term child outcomes. Our main objective was to identify factors associated with timing of ASD diagnosis in five provinces across Canada. Factors influencing age of diagnosis were assessed in the analyses of an inception cohort of children diagnosed with ASD between ages 2 and 5 years. We examined bivariate associations and using a series of multiple variable regression models, evaluated the unique contributions of developmental functioning, ASD symptoms and demographic variables. Children with known genetic abnormalities, or severe sensory or motor impairments interfering with assessment were excluded. Participants were 421 children (84.6% boys). The mean age of diagnosis was 38.2 months (SD=8.7), an average of 19 months after parents identified initial concerns. Factors associated with later diagnosis included more advanced language and cognitive skills, and higher levels of restricted repetitive behaviour symptoms. Child sex and family demographics were Diagnosis of ASD occurred, on average, 19 months after parents' initial concerns. Language and cognitive skills, symptom severity and provincial site accounted for variation in age of ASD diagnosis in this Canadian cohort. Variable presentation across the developmental continuum must be considered in planning assessment services to ensure timely ASD diagnosis so that outcomes can be improved. Policy and practice leadership is also needed to reduce interprovincial variability.

Sections du résumé

BACKGROUND BACKGROUND
Early diagnosis of autism spectrum disorder (ASD) is essential in most Canadian jurisdictions to access interventions that improve long-term child outcomes. Our main objective was to identify factors associated with timing of ASD diagnosis in five provinces across Canada.
METHODS METHODS
Factors influencing age of diagnosis were assessed in the analyses of an inception cohort of children diagnosed with ASD between ages 2 and 5 years. We examined bivariate associations and using a series of multiple variable regression models, evaluated the unique contributions of developmental functioning, ASD symptoms and demographic variables. Children with known genetic abnormalities, or severe sensory or motor impairments interfering with assessment were excluded.
RESULTS RESULTS
Participants were 421 children (84.6% boys). The mean age of diagnosis was 38.2 months (SD=8.7), an average of 19 months after parents identified initial concerns. Factors associated with later diagnosis included more advanced language and cognitive skills, and higher levels of restricted repetitive behaviour symptoms. Child sex and family demographics were
INTERPRETATION CONCLUSIONS
Diagnosis of ASD occurred, on average, 19 months after parents' initial concerns. Language and cognitive skills, symptom severity and provincial site accounted for variation in age of ASD diagnosis in this Canadian cohort. Variable presentation across the developmental continuum must be considered in planning assessment services to ensure timely ASD diagnosis so that outcomes can be improved. Policy and practice leadership is also needed to reduce interprovincial variability.

Identifiants

pubmed: 30906197
doi: 10.1093/pch/pxy076
pii: pxy076
pmc: PMC6376294
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e57-e65

Références

Dev Med Child Neurol. 1999 Dec;41(12):834-9
pubmed: 10619282
J Autism Dev Disord. 2000 Jun;30(3):205-23
pubmed: 11055457
Pediatrics. 2005 Dec;116(6):1480-6
pubmed: 16322174
J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S79-87
pubmed: 16685189
J Child Psychol Psychiatry. 2006 Jun;47(6):582-90
pubmed: 16712635
Autism. 2006 Sep;10(5):439-51
pubmed: 16940311
J Autism Dev Disord. 2007 Apr;37(4):613-27
pubmed: 17180459
J Autism Dev Disord. 2007 Jan;37(1):62-72
pubmed: 17195921
Pediatrics. 2007 Nov;120(5):1183-215
pubmed: 17967920
Autism. 2008 Sep;12(5):487-511
pubmed: 18805944
Autism. 2008 Sep;12(5):537-56
pubmed: 18805946
J Autism Dev Disord. 2009 May;39(5):693-705
pubmed: 19082876
Am J Intellect Dev Disabil. 2009 Jan;114(1):23-41
pubmed: 19143460
J Autism Dev Disord. 2009 Jul;39(7):986-95
pubmed: 19263208
J Am Acad Child Adolesc Psychiatry. 2009 May;48(5):474-83
pubmed: 19318992
Chronic Dis Can. 2009;29(3):102-7
pubmed: 19527568
Can J Public Health. 2009 Jul-Aug;100(4):268-73
pubmed: 19722339
Pediatrics. 2010 Jan;125(1):e17-23
pubmed: 19948568
Psychiatr Serv. 2010 Aug;61(8):822-9
pubmed: 20675842
Chronic Dis Can. 2010 Sep;30(4):125-34
pubmed: 20946713
J Epidemiol Community Health. 2011 Jun;65(6):503-10
pubmed: 20974836
Autism. 2013 Mar;17(2):184-95
pubmed: 21788254
Chronic Dis Inj Can. 2012 Mar;32(2):90-100
pubmed: 22414306
Res Dev Disabil. 2012 Nov-Dec;33(6):1763-72
pubmed: 22705454
Autism Res Treat. 2011;2011:874619
pubmed: 22937257
J Autism Dev Disord. 2014 Oct;44(10):2400-12
pubmed: 23143131
Autism. 2014 Jul;18(5):583-97
pubmed: 23787411
CMAJ. 2014 Apr 15;186(7):509-19
pubmed: 24418986
MMWR Surveill Summ. 2014 Mar 28;63(2):1-21
pubmed: 24670961
J Autism Dev Disord. 2015 Aug;45(8):2411-28
pubmed: 25737021
J Child Psychol Psychiatry. 2015 Sep;56(9):988-98
pubmed: 25921776
J Autism Dev Disord. 2015 Sep;45(9):2833-47
pubmed: 25936527
J Am Acad Child Adolesc Psychiatry. 2015 Jun;54(6):470-8
pubmed: 26004662
Child Care Health Dev. 2016 Jan;42(1):141-5
pubmed: 26016520
Pediatrics. 2015 Oct;136 Suppl 1:S10-40
pubmed: 26430168
Pediatrics. 2015 Oct;136 Suppl 1:S60-81
pubmed: 26430170
CMAJ Open. 2015 Jul 17;3(3):E276-80
pubmed: 26442225
Autism Res. 2016 Jul;9(7):790-800
pubmed: 26613202
MMWR Surveill Summ. 2016 Apr 01;65(3):1-23
pubmed: 27031587
J Autism Dev Disord. 2016 Jun;46(6):1974-1984
pubmed: 27032954
J Autism Dev Disord. 1994 Oct;24(5):659-85
pubmed: 7814313
Eur Child Adolesc Psychiatry. 1998 Sep;7(3):131-6
pubmed: 9826299

Auteurs

Lonnie Zwaigenbaum (L)

Department of Pediatrics, University of Alberta, Edmonton, Alberta.
Pediatric Division, Glenrose Rehabilitation Hospital, Edmonton, Alberta.

Eric Duku (E)

Offord Centre for Child Studies and McMaster Autism Research Team, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario.

Eric Fombonne (E)

Departments of Psychiatry, Pediatrics and Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA.

Peter Szatmari (P)

Department of Psychiatry, University of Toronto, Toronto, Ontario.
Department of Psychiatry, Hospital for Sick Children and Centre for Addiction and Mental Health, Toronto, Ontario.

Isabel M Smith (IM)

Autism Research Centre, IWK Health Centre, Halifax, Nova Scotia.
Departments of Pediatrics, Psychology and Neurosciences, Dalhousie University, Halifax, Nova Scotia.

Susan E Bryson (SE)

Autism Research Centre, IWK Health Centre, Halifax, Nova Scotia.
Departments of Pediatrics, Psychology and Neurosciences, Dalhousie University, Halifax, Nova Scotia.

Pat Mirenda (P)

Departments of Educational and Counselling Psychology and Special Education, University of British Columbia, Vancouver, British Columbia.

Tracy Vaillancourt (T)

Counselling Psychology, Faculty of Education, University of Ottawa, Ottawa, Ontario.

Joanne Volden (J)

Department of Communication Sciences and Disorders, University of Alberta, Edmonton, Alberta.

Stelios Georgiades (S)

Offord Centre for Child Studies and McMaster Autism Research Team, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario.

Wendy Roberts (W)

Integrated Services for Autism and Neurodevelopmental Disorders, Toronto, Ontario.

Teresa Bennett (T)

Offord Centre for Child Studies and McMaster Autism Research Team, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario.

Mayada Elsabbagh (M)

Montreal Neurological Institute, McGill University, Montreal, Quebec.

Charlotte Waddell (C)

Faculty of Health Sciences, Children's Health Policy Centre, Simon Fraser University, Vancouver, British Columbia.

Mandy Steiman (M)

Department of Psychiatry, McGill University, Montreal, Quebec.

Rebecca Simon (R)

Department of Psychiatry, McGill University, Montreal, Quebec.

Ruth Bruno (R)

Department of Psychiatry, McGill University, Montreal, Quebec.

Classifications MeSH