C5b9 Deposition in Glomerular Capillaries Is Associated With Poor Kidney Allograft Survival in Antibody-Mediated Rejection.
Adult
Allografts
/ immunology
Antibodies
/ immunology
Capillaries
/ immunology
Complement Activation
/ immunology
Complement Membrane Attack Complex
/ immunology
Female
Graft Rejection
/ immunology
Humans
Kidney Diseases
/ immunology
Kidney Glomerulus
/ immunology
Kidney Transplantation
/ adverse effects
Kidney Tubules
/ immunology
Male
Middle Aged
Renal Artery
/ immunology
Retrospective Studies
C4d
C5b9
antibody-mediated rejection
complement
kidney transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
11
2018
accepted:
28
01
2019
entrez:
26
3
2019
pubmed:
25
3
2019
medline:
27
5
2020
Statut:
epublish
Résumé
C4d deposition in peritubular capillaries (PTC) reflects complement activation in antibody-mediated rejection (ABMR) of kidney allograft. However, its association with allograft survival is controversial. We hypothesized that capillary deposition of C5b9-indicative of complement-mediated injury-is a severity marker of ABMR. This pilot study aimed to determine the frequency, location and prognostic impact of these deposits in ABMR. We retrospectively selected patients diagnosed with ABMR in two French transplantation centers from January 2005 to December 2014 and performed C4d and C5b9 staining by immunohistochemistry. Fifty-four patients were included. Median follow-up was 52.5 (34.25-73.5) months. Thirteen patients (24%) had C5b9 deposits along glomerular capillaries (GC). Among these, seven (54%) had a global and diffuse staining pattern. Twelve of the C5b9+ patients also had deposition of C4d in GC and PTC. C4d deposits along GC and PTC were not associated with death-censored allograft survival (
Identifiants
pubmed: 30906289
doi: 10.3389/fimmu.2019.00235
pmc: PMC6418012
doi:
Substances chimiques
Antibodies
0
Complement Membrane Attack Complex
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
235Références
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