Recent advances in the first-line treatment of follicular non-Hodgkin lymphoma.


Journal

F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320

Informations de publication

Date de publication:
2019
Historique:
accepted: 08 03 2019
entrez: 26 3 2019
pubmed: 25 3 2019
medline: 6 6 2020
Statut: epublish

Résumé

Follicular lymphoma (FL) is the most common type of indolent B-cell lymphoma. Twenty years ago, FL was considered an indolent lymphoma with a long survival time but without a high rate of complete remission with chemotherapies. The use of rituximab has improved the response and survival of patients with this lymphoma. More recently, development of biological knowledge and use of targeted drugs have offered new perspectives, including improvement of response rates and survival with chemo-free treatment strategies. In 2019, patients have a 10-year overall survival probability of over 70%. Histological transformation to more aggressive lymphoma and treatment relapses remain a medical challenge, especially for patients relapsing within two years. This article will review the recent advances in the treatment of FL. As the use of new drugs is directly related to the development of biological aspects, we will first summarize recent advances in biological aspects of FL.

Identifiants

pubmed: 30906531
doi: 10.12688/f1000research.16686.1
pmc: PMC6426075
pii:
doi:

Substances chimiques

Rituximab 4F4X42SYQ6

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

Competing interests: PF received reimbursements and fees in the past 5 years for Roche, Gilead, Janssen, Abbvie and Celgene companies. LFC has no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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Auteurs

Pierre Feugier (P)

Department of Hematology, CHRU Nancy Brabois, Vandoeuvre les Nancy, France.
Unité INSERM 1256, Faculté de Médecine, Université de Lorraine, Lorraine, France.

Lauriane Filliatre-Clement (L)

Department of Hematology, CHRU Nancy Brabois, Vandoeuvre les Nancy, France.

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