Opuntia ficus-indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti-angiogenic properties.
Opuntia ficus-indica (L.) Mill
anti-angiogenic properties
antioxidant activity
betalains
cactus pear
cytoprotective activity
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
04
01
2019
revised:
18
02
2019
accepted:
19
02
2019
pubmed:
25
3
2019
medline:
14
8
2019
entrez:
26
3
2019
Statut:
ppublish
Résumé
The aim of this work was to investigate the phytochemical profile and biological properties of different colours of betalain cactus pear extracts, evaluating their antioxidant, cytoprotective, and anti-angiogenic properties by cell-free, cell-based, and in vivo assays. A QuEChERS extraction method followed by RP-LC-DAD-MS/MS analysis showed that indicaxanthin and betanin were the main compounds (≥94.32% and ≥96.95%, respectively). Orange cactus pear extracts exert the best antioxidant activity in all assays carried out, in particular into ORAC (17,352.55 ± 987.407 mg trolox equivalents/100 g dry weight) and β-carotene bleaching (60.35%) assays. The red ones, instead, showed the best cytoprotective activity decreasing the cell mortality, LDH, and Caspase-3 release ranging from 4.0 to 55%. According to antioxidant results, the orange cactus pear extracts showing also the highest anti-angiogenic activity (IC
Substances chimiques
Antioxidants
0
Phytochemicals
0
Plant Extracts
0
Betalains
37279-84-8
Types de publication
Journal Article
Langues
eng
Pagination
1526-1537Informations de copyright
© 2019 John Wiley & Sons, Ltd.