Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.

Brain Neoplasms / drug therapy Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects Cyanoacrylates / therapeutic use Dynamin II / antagonists & inhibitors Glioma / drug therapy Humans Indoles / therapeutic use Molecular Targeted Therapy / methods Neoplastic Stem Cells / drug effects Tumor Burden / drug effects Xenograft Model Antitumor Assays
Cancer biology Cancer stem cells Dynamin Glioblastoma Invasion

Journal

Cancer investigation
ISSN: 1532-4192
Titre abrégé: Cancer Invest
Pays: England
ID NLM: 8307154

Informations de publication

Date de publication:
2019
Historique:
pubmed: 26 3 2019
medline: 30 4 2019
entrez: 26 3 2019
Statut: ppublish

Résumé

Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.

Identifiants

DOI: 10.1080/07357907.2019.1582060 PMID: 30907150
pubmed: 30907150
doi: 10.1080/07357907.2019.1582060
doi:

Substances chimiques

Cyanoacrylates 0
Indoles 0
dynole 34-2 0
Dynamin II EC 3.6.5.5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

144-155

Auteurs

Rodney Luwor (R)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.

Andrew P Morokoff (AP)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
b Department of Neurosurgery , The Royal Melbourne Hospital , Parkville , Australia.

Stephanie Amiridis (S)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
c Department of Medicine , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.

Giovanna D'Abaco (G)

d Melbourne School of Engineering, School of Chemical and Biomedical Engineering , The University of Melbourne , Parkville , Australia.

Lucia Paradiso (L)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.

Stanley S Stylli (SS)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
b Department of Neurosurgery , The Royal Melbourne Hospital , Parkville , Australia.

Hong P T Nguyen (HPT)

a Department of Surgery , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.

Mark Tarleton (M)

e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.

Kelly A Young (KA)

e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.

Terence J O'Brien (TJ)

c Department of Medicine , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
f Department of Neuroscience , Central Clinical School, Monash University , Melbourne , Australia.
g Department of Neurology , The Alfred Hospital , Melbourne , Australia.

Phillip J Robinson (PJ)

e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.
h Children's Medical Research Institute, The University of Sydney , Westmead , Australia.
ORCID: 0000-0002-7878-0313

Megan Chircop (M)

e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.
h Children's Medical Research Institute, The University of Sydney , Westmead , Australia.

Adam McCluskey (A)

e Department of Chemistry, School of Environmental and Life Sciences , The University of Newcastle , Callaghan , Australia.

Nigel C Jones (NC)

c Department of Medicine , The University of Melbourne, The Royal Melbourne Hospital , Parkville , Australia.
f Department of Neuroscience , Central Clinical School, Monash University , Melbourne , Australia.
g Department of Neurology , The Alfred Hospital , Melbourne , Australia.
ORCID: 0000-0002-1080-8439

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Adhésifs tissulaires › Cyanoacrylates › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Dynamines › Dynamine-II › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Targeting Glioma Stem Cells by Functional...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Targeting Glioma Stem Cells by Functional...