Folliculitis decalvans is characterized by a persistent, abnormal subepidermal microbiota.
Cutibacterium acnes
Staphylococcus aureus
folliculitis decalvans
scalp microbiota
subepidermal microbiota
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
22
10
2018
revised:
03
02
2019
accepted:
18
02
2019
pubmed:
26
3
2019
medline:
28
9
2021
entrez:
26
3
2019
Statut:
ppublish
Résumé
Folliculitis decalvans (FD) is a chronic inflammatory disease of unknown aetiology. Although Staphylococcus aureus, frequently found on lesional skin, is thought to play a causal role, the importance of its involvement remains controversial. To examine the role of S aureus, we compared superficial and subepidermal microbiota in 20 FD patients who had S aureus on lesional skin and in 20 healthy controls using culture techniques and genomic identification, before and after an anti-staphylococcal treatment; we also screened for S aureus virulence factors. When present on lesional skin, S aureus colonized non-lesional and subepidermal skin in 80% of cases. These data imply a break in the epidermal barrier integrity and that an abnormal non-lesional skin microbiota persists in FD. S aureus had no superantigenic toxin in 31% of cases and no toxin specificity. Clinical improvement obtained in most cases upon treatment was associated with the disappearance of S aureus in all studied areas, with an incomplete restoration of normal microbiota and a significant increase in negative bacterial samples. This persistent unbalanced, subepidermal microbiota may act as a reservoir of abnormal flora and explain the chronicity of FD, suggesting new avenues of research to restore normal microbiota.
Substances chimiques
Superantigens
0
Virulence Factors
0
Banques de données
ClinicalTrials.gov
['NCT02157688']
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
295-298Subventions
Organisme : French Ministry of Health
ID : PHRC 2011
Pays : International
Organisme : French Ministry of Health
ID : NCT02157688
Pays : International
Organisme : SVR company
Pays : International
Organisme : Phytosolba company
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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