Contribution of obesity associated genetic variants to anthropometric somatotype components.
Adolescent
Adult
Aged
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/ genetics
Anthropometry
Body Mass Index
Brain-Derived Neurotrophic Factor
/ genetics
Case-Control Studies
Humans
Middle Aged
Nerve Tissue Proteins
/ genetics
Obesity
/ genetics
Polymorphism, Single Nucleotide
Somatotypes
Spain
Young Adult
Journal
Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur
ISSN: 0003-5548
Titre abrégé: Anthropol Anz
Pays: Germany
ID NLM: 0372377
Informations de publication
Date de publication:
24 Jun 2019
24 Jun 2019
Historique:
received:
10
10
2018
revised:
24
01
2019
accepted:
04
02
2019
pubmed:
26
3
2019
medline:
27
8
2019
entrez:
26
3
2019
Statut:
ppublish
Résumé
The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association between SNPs and the somatotype. Two genetic variants (rs925946 in BDNF and rs10146997 in NRXN3) showed a significant association with endomorphy (
Identifiants
pubmed: 30907917
doi: 10.1127/anthranz/2019/0945
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Nerve Tissue Proteins
0
neurexin IIIalpha
0
BDNF protein, human
7171WSG8A2
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
Types de publication
Journal Article
Langues
eng