Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment.
Acetates
/ chemistry
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Chelating Agents
/ chemical synthesis
Copper
/ chemistry
DNA Cleavage
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Ligands
Molecular Structure
Organometallic Compounds
/ chemical synthesis
Pregnenolone
/ chemistry
Reactive Oxygen Species
/ metabolism
Structure-Activity Relationship
Tumor Cells, Cultured
Uterine Cervical Neoplasms
/ drug therapy
Apoptosis
Copper
DNA damage
Pregnenolone acetate
Redox cycling
Tetrazole
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
06
12
2018
revised:
26
02
2019
accepted:
14
03
2019
pubmed:
26
3
2019
medline:
23
9
2020
entrez:
26
3
2019
Statut:
ppublish
Résumé
Cervical cancer is a leading cause of cancer-related deaths among women in developing countries. Therefore, development of new chemotherapeutic agents is required. Unlike normal cells, cancer cells contain elevated copper levels which play an integral role in angiogenesis. Thus, targeting copper via copper-specific chelators in cancer cells can serve as effective anticancer strategy. In this work, a copper chelator pregnenolone acetate nucleus-based tetrazole derivative (ligand-L) was synthesized and characterized by elemental analysis, ESI-MS,
Identifiants
pubmed: 30908970
pii: S0045-2068(18)31423-8
doi: 10.1016/j.bioorg.2019.03.031
pii:
doi:
Substances chimiques
Acetates
0
Antineoplastic Agents
0
Chelating Agents
0
Ligands
0
Organometallic Compounds
0
Reactive Oxygen Species
0
Pregnenolone
73R90F7MQ8
Copper
789U1901C5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
276-290Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.