Antiplasmodial Lycorane Alkaloid Principles of the Plant Family Amaryllidaceae.

The spread of malaria is thought to have followed human expansion out of Africa some 60 - 80 thousand years ago. With its prevalence in pantropical countries of the world and epicenter localized in Africa, malaria is now considered an unnecessary burden to overworked and under-resourced healthcare structures. Plants have long afforded a fertile hunting ground for the search and identification of structurally diverse antimalarial agents, such as quinine and artemisinin. This survey examines the antiparasitic properties of the family Amaryllidaceae via the antiplasmodial activities demonstrated for its lycorane alkaloid principles. Of these, 24 were natural compounds identified in 20 species from 11 genera of the Amaryllidaceae family, whilst the remaining 28 were synthetically derived entities based on the lycorane skeleton. These were screened against ten different strains of the malarial parasite

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Georg Thieme Verlag KG Stuttgart · New York.

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The findings described herein are a consolidation of independent research carried out in the laboratories of the authors. As such, none of its content in any shape or form is deemed liable to any other individual or organization.