A Review of the Clinical Pharmacokinetics of Polymyxin B.
pharmacokinetics
polymyxin B
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
22 Mar 2019
22 Mar 2019
Historique:
received:
20
02
2019
revised:
12
03
2019
accepted:
15
03
2019
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
27
3
2019
Statut:
epublish
Résumé
Polymyxin B remains an antibiotic of last resort because of its toxicities. Although newer therapies are becoming available, it is anticipated that resistance to these agents will continue to emerge, and understanding the safest and most efficacious manner to deliver polymyxin B will remain highly important. Recent data have demonstrated that polymyxin B may be less nephrotoxic than colistin. Pharmacokinetically, polymyxin B is primarily eliminated via non-renal pathways, and most do not recommend adjusting the dose for renal impairment. However, some recent studies suggest a weak relationship between polymyxin B clearance and patient creatinine clearance. This review article will describe the clinical pharmacokinetics of polymyxin B and address relevant issues in chemistry and assays available.
Identifiants
pubmed: 30909507
pii: antibiotics8010031
doi: 10.3390/antibiotics8010031
pmc: PMC6466567
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : U19 AI135964
Pays : United States
Déclaration de conflit d'intérêts
Authors declare no relevant conflict of interest.
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