2,4 Dinitrophenol as Medicine.
2,4-dinitrophenol (DNP)
Brain-derived neurotrophic factor (BDNF)
Duchenne Muscular Dystrophy
Huntington’s Disease
Multiple Sclerosis
Traumatic Brain Injury
anti-aging
metabesity
mitochondrial uncoupler
neurodegeneration
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 03 2019
23 03 2019
Historique:
received:
10
01
2019
revised:
11
03
2019
accepted:
20
03
2019
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
27
3
2019
Statut:
epublish
Résumé
In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950's to suggest that warfarin, a rat poison, could be repositioned into a breakthrough drug in humans to protect against strokes as a blood thinner. Yet it was approved in 1954 as Coumadin
Identifiants
pubmed: 30909602
pii: cells8030280
doi: 10.3390/cells8030280
pmc: PMC6468406
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Adenosine Triphosphate
8L70Q75FXE
2,4-Dinitrophenol
Q13SKS21MN
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Biochem J. 2007 Oct 1;407(1):129-40
pubmed: 17608618
J Neurotrauma. 1997 Jan;14(1):23-34
pubmed: 9048308
Hear Res. 2017 Jun;349:21-30
pubmed: 27913314
Turk J Urol. 2017 Dec;43(4):410-413
pubmed: 29201500
J Diabetes Complications. 2015 Apr;29(3):367-71
pubmed: 25682570
Med Sci Sports Exerc. 2011 Aug;43(8):1575-81
pubmed: 21681120
Hum Mol Genet. 1999 Mar;8(3):397-407
pubmed: 9949199
Neuromuscul Disord. 2014 May;24(5):393-401
pubmed: 24491484
Free Radic Biol Med. 2009 Aug 15;47(4):333-43
pubmed: 19427899
Exp Neurol. 2002 Oct;177(2):419-27
pubmed: 12429188
Diabetes Care. 2012 Feb;35(2):358-62
pubmed: 22210566
FASEB J. 2013 Jun;27(6):2521-30
pubmed: 23482635
Adv Exp Med Biol. 2004;548:34-56
pubmed: 15250584
Indian Pediatr. 2017 Jun 15;54(6):453-454
pubmed: 28667714
Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2561-8
pubmed: 25064589
Am J Physiol. 1995 Nov;269(5 Pt 2):R1213-24
pubmed: 7503313
Biochimie. 2013 Jan;95(1):86-90
pubmed: 23009927
Arch Neurol. 2008 Apr;65(4):476-80
pubmed: 18413469
Front Physiol. 2014 Jun 23;5:231
pubmed: 25002850
Orphanet J Rare Dis. 2013 Feb 12;8:23
pubmed: 23398819
Clin Biochem. 2011 Jul;44(10-11):817-20
pubmed: 21620811
Handb Clin Neurol. 2018;153:321-335
pubmed: 29887143
FASEB J. 2004 Sep;18(12):1366-72
pubmed: 15333579
Hum Mol Genet. 2013 Jan 1;22(1):153-67
pubmed: 23049075
J Neurosci. 2011 Oct 5;31(40):14182-90
pubmed: 21976503
J Neurochem. 2005 Sep;94(6):1676-84
pubmed: 16045446
Heart Vessels. 2018 Nov;33(11):1325-1333
pubmed: 29700574
Neurology. 2012 Mar 6;78(10):690-5
pubmed: 22323755
J Cell Biol. 2010 Dec 27;191(7):1225-7
pubmed: 21187326
J Neurosci Res. 2018 Oct;96(10):1677-1688
pubmed: 30063076
Behav Brain Res. 2015 Jul 15;288:107-17
pubmed: 25841616
Diabetes Obes Metab. 2002 Jul;4(4):262-9
pubmed: 12099975
Neurol Neuroimmunol Neuroinflamm. 2015 Jul 23;2(4):e135
pubmed: 26236761
Nat Commun. 2016 Nov 22;7:13548
pubmed: 27874000
Annu Rev Pharmacol Toxicol. 2001;41:145-74
pubmed: 11264454
J Biol Chem. 2003 May 23;278(21):19062-70
pubmed: 12660243
Biochem Biophys Res Commun. 1997 Sep 18;238(2):633-7
pubmed: 9299565
Front Aging Neurosci. 2014 Apr 22;6:78
pubmed: 24795630
Science. 1993 Oct 29;262(5134):689-95
pubmed: 7901908
Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H767-75
pubmed: 23335798
Cell. 2014 Mar 27;157(1):163-86
pubmed: 24679534
Lancet. 2018 Feb 3;391(10119):451-461
pubmed: 29174484
Regul Toxicol Pharmacol. 2007 Jul;48(2):115-7
pubmed: 17475379
Rev Neurol (Paris). 2018 Jun;174(6):408-418
pubmed: 29673573
PLoS One. 2012;7(7):e40604
pubmed: 22792385
Front Behav Neurosci. 2014 Dec 04;8:417
pubmed: 25538582
PLoS One. 2011 Jan 05;6(1):e15961
pubmed: 21246038
J Neurotrauma. 2011 Sep;28(9):1845-53
pubmed: 21875332
Brain. 2010 Aug;133(Pt 8):2248-63
pubmed: 20826430
Med Sci Sports Exerc. 1993 Jan;25(1):71-80
pubmed: 8292105
Clin Drug Investig. 2016 May;36(5):341-56
pubmed: 27021968
Toxicol Appl Pharmacol. 2004 Apr 1;196(1):68-79
pubmed: 15050409
Biomed Res Int. 2015;2015:617207
pubmed: 25874222
Am J Public Health Nations Health. 1934 Oct;24(10):1045-53
pubmed: 18014064
Cell Signal. 2018 Jan;42:281-291
pubmed: 29175000
Metabolism. 2006 Oct;55(10):1286-92
pubmed: 16979397
Endocrinology. 2013 Sep;154(9):3099-109
pubmed: 23766126
Neurotox Res. 2010 Aug;18(2):112-23
pubmed: 19949915
Front Aging Neurosci. 2017 Apr 03;9:89
pubmed: 28420983
Exp Eye Res. 2012 Jul;100:1-6
pubmed: 22561341
Immunol Rev. 2005 Apr;204:208-31
pubmed: 15790361
Neurochem Int. 2015 Feb;81:16-27
pubmed: 25595039
Hum Mol Genet. 2016 Jan 1;25(1):130-45
pubmed: 26566673
Hum Mol Genet. 2013 Jun 15;22(12):2462-70
pubmed: 23446639
Glia. 2018 Feb;66(2):359-378
pubmed: 29086442
Diabetologia. 2011 Feb;54(2):237-44
pubmed: 20953861
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
Nature. 1961 Jul 8;191:144-8
pubmed: 13771349
Cell Metab. 2012 Dec 5;16(6):706-22
pubmed: 23168220
Curr Alzheimer Res. 2007 Jul;4(3):263-71
pubmed: 17627483
Mol Neurobiol. 2018 Dec;55(12):8765-8787
pubmed: 29594942
Oxid Med Cell Longev. 2014;2014:195935
pubmed: 24987493
Cell. 1987 Dec 24;51(6):919-28
pubmed: 3319190
Brain Res. 2017 May 15;1663:184-193
pubmed: 28322751
IUBMB Life. 2006 Apr;58(4):185-91
pubmed: 16754295
Curr Aging Sci. 2010 Feb;3(1):20-5
pubmed: 20298166
Hum Mol Genet. 2012 May 15;21(10):2245-62
pubmed: 22337954
J Neurosci Res. 2007 Feb 15;85(3):525-35
pubmed: 17149751
Trends Endocrinol Metab. 2015 Sep;26(9):486-492
pubmed: 26138757
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5061-5
pubmed: 1647024
J Pharm Sci. 2013 Jan;102(1):34-42
pubmed: 23147500
Cell. 2010 Nov 24;143(5):802-12
pubmed: 21094524
Nat Rev Drug Discov. 2016 Nov 3;15(11):733-735
pubmed: 27807361
Am J Physiol. 1986 Nov;251(5 Pt 1):E576-83
pubmed: 3535532
J Neurotrauma. 2010 May;27(5):829-41
pubmed: 20143955
Aging Cell. 2008 Aug;7(4):552-60
pubmed: 18505478
Int J Obes Relat Metab Disord. 2001 Sep;25(9):1286-93
pubmed: 11571589
Eur J Neurosci. 2014 Mar;39(6):1042-56
pubmed: 24372914
FASEB J. 2005 Oct;19(12):1627-36
pubmed: 16195371
Nat Neurosci. 2002 Aug;5(8):731-6
pubmed: 12089530
Science. 2015 Mar 13;347(6227):1253-6
pubmed: 25721504
Mol Cell Endocrinol. 2017 Nov 5;455:4-12
pubmed: 28137612
Mech Ageing Dev. 2010 Jul-Aug;131(7-8):480-6
pubmed: 20434479
Brain Sci. 2015 Jul 29;5(3):275-98
pubmed: 26230713
Life Sci. 1995;56(14):1151-71
pubmed: 7475893
Autophagy. 2015;11(2):385-402
pubmed: 25758767
Mitochondrion. 2012 Jan;12(1):35-40
pubmed: 21530687
Neural Regen Res. 2018 Aug;13(8):1338-1341
pubmed: 30106036
JPEN J Parenter Enteral Nutr. 1999 May-Jun;23(3):160-8
pubmed: 10338224
Biochim Biophys Acta. 2006 Jan;1757(1):21-30
pubmed: 16375850
N Engl J Med. 1998 Feb 5;338(6):362-6
pubmed: 9449729
Cell Metab. 2013 Nov 5;18(5):740-8
pubmed: 24206666
Exp Physiol. 2017 Mar 1;102(3):314-328
pubmed: 28070911
Exp Neurol. 2000 Feb;161(2):631-7
pubmed: 10686082
Neurology. 2007 May 29;68(22 Suppl 3):S13-21; discussion S43-54
pubmed: 17548563
Diabetes. 1999 Mar;48(3):588-94
pubmed: 10078561
Am J Pathol. 2010 May;176(5):2414-24
pubmed: 20304955
JAMA. 2000 Jan 5;283(1):69-73
pubmed: 10632282
Am J Physiol. 1996 Oct;271(4 Pt 1):C1380-9
pubmed: 8897845
Alzheimers Dement. 2017 May;13(5):582-591
pubmed: 27599210
Diabetes. 2014 Mar;63(3):923-33
pubmed: 24227685
Epilepsia. 2001 Nov;42(11):1371-8
pubmed: 11879337
Ageing Res Rev. 2012 Jul;11(3):347-52
pubmed: 22394472
Adv Exp Med Biol. 2012;724:205-21
pubmed: 22411245
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4447-52
pubmed: 15070738
Curr Med Chem. 2003 Aug;10(16):1485-506
pubmed: 12871122
Antioxid Redox Signal. 2009 Jun;11(6):1265-78
pubmed: 19281299
Brain Res Bull. 2004 Jul 30;64(1):47-51
pubmed: 15275956
J Clin Invest. 1992 Oct;90(4):1323-7
pubmed: 1401068
Ageing Res Rev. 2017 Oct;39:46-58
pubmed: 27810402
Diabetes Obes Metab. 2007 Jan;9(1):59-64
pubmed: 17199719
Pharmaceuticals (Basel). 2009 Oct 14;2(3):77-81
pubmed: 27713225
Dis Model Mech. 2017 Nov 1;10(11):1343-1352
pubmed: 29125827
Science. 1989 Oct 27;246(4929):500-3
pubmed: 2814477
Int J Exp Diabetes Res. 2001;2(3):201-9
pubmed: 12369708
Biochem Soc Trans. 2003 Dec;31(Pt 6):1300-1
pubmed: 14641047
Trans Am Ophthalmol Soc. 1941;39:405-37
pubmed: 16693262
Oxid Med Cell Longev. 2017;2017:7180632
pubmed: 28680531
Ann N Y Acad Sci. 2010 Jul;1201:96-103
pubmed: 20649545
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2911-6
pubmed: 12589027
J Neurotrauma. 2007 May;24(5):798-811
pubmed: 17518535
Mamm Genome. 1998 Apr;9(4):274-82
pubmed: 9530622
Science. 2001 Nov 2;294(5544):1030-8
pubmed: 11691980
Rev Neurol (Paris). 2017 Mar;173(3):106-113
pubmed: 28238346
Cell Metab. 2014 Feb 4;19(2):181-92
pubmed: 24440038
Nat Immunol. 2007 Sep;8(9):913-9
pubmed: 17712344
Neuropharmacology. 2013 Nov;74:86-95
pubmed: 23357335
Ann Neurosci. 2014 Oct;21(4):129-33
pubmed: 25452672
PLoS One. 2010 Feb 11;5(2):e9176
pubmed: 20161803
J Neuroimmunol. 2016 Oct 15;299:53-58
pubmed: 27725121
J Clin Invest. 2007 Mar;117(3):739-45
pubmed: 17318260
Diabetes. 2005 Mar;54(3):603-8
pubmed: 15734833
Alzheimers Dement. 2011 Jan;7(1):61-73
pubmed: 21255744
Neuron. 2002 Aug 15;35(4):605-23
pubmed: 12194863
Physiology (Bethesda). 2017 Jan;32(1):9-19
pubmed: 27927801
Diabetes. 2000 Mar;49(3):436-44
pubmed: 10868966
Exp Neurol. 2008 Mar;210(1):154-63
pubmed: 18096160
Mol Pharmacol. 2002 Jul;62(1):22-9
pubmed: 12065751
Endocrinology. 2013 Mar;154(3):1021-8
pubmed: 23364948
PLoS One. 2011 Feb 17;6(2):e17118
pubmed: 21359198
Front Neuroenergetics. 2013 Dec 18;5:10
pubmed: 24385963
Nat Med. 2008 Apr;14(4):442-7
pubmed: 18345011
Med Hypotheses. 2015 Dec;85(6):1021-33
pubmed: 26365249
J Neurochem. 2013 Aug;126 Suppl 1:94-102
pubmed: 23859345
Ann Neurol. 2006 Mar;59(3):478-89
pubmed: 16392116
FASEB J. 2001 May;15(7):1297-9
pubmed: 11344119
Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1198-206
pubmed: 25234311
J Neurochem. 2015 Aug;134(4):677-92
pubmed: 26010875
Nat Rev Neurol. 2014 Apr;10(4):204-16
pubmed: 24614516
J Cell Biol. 1981 Dec;91(3 Pt 2):227s-255s
pubmed: 7033239
Brain Res Dev Brain Res. 1995 Apr 18;85(2):249-58
pubmed: 7541321
Curr Top Microbiol Immunol. 2018;414:73-102
pubmed: 28349285
Aging Cell. 2017 Feb;16(1):73-81
pubmed: 27619151
J Neurol Sci. 2011 Jan 15;300(1-2):103-6
pubmed: 20932539
J Clin Invest. 2017 Jun 1;127(6):2418-2432
pubmed: 28481224
Nord J Psychiatry. 2016;70(4):267-71
pubmed: 26548545
Neurology. 1995 Feb;45(2):244-50
pubmed: 7854520
Int J Neuropsychopharmacol. 2016 Apr 7;19(6):
pubmed: 27207906
J Neurotrauma. 1998 Oct;15(10):789-98
pubmed: 9814635
Hum Mol Genet. 2016 Jul 15;25(14):3029-3041
pubmed: 27288453
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
J Biol Chem. 2004 Jul 30;279(31):32345-53
pubmed: 15166226
Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2555-60
pubmed: 24907564
Neurobiol Dis. 2013 Mar;51:3-12
pubmed: 22266017
Brain Dev. 2008 Jun;30(6):391-5
pubmed: 18180123
Exp Neurol. 2017 Jul;293:83-90
pubmed: 28359739
Cell. 1987 Jul 31;50(3):509-17
pubmed: 3607877
Biosci Rep. 2006 Jun;26(3):231-43
pubmed: 16850251
J Neurosci. 2001 Jun 15;21(12):4183-7
pubmed: 11404403
Diabetes. 2002 Jul;51(7):2158-69
pubmed: 12086946
J Med Toxicol. 2011 Sep;7(3):205-12
pubmed: 21739343
Ageing Res Rev. 2017 Oct;39:68-77
pubmed: 28216454
Br J Pharmacol. 2014 Apr;171(8):2017-28
pubmed: 24134698
J Biomed Biotechnol. 2011;2011:201696
pubmed: 21960735
Biochim Biophys Acta. 2015 Apr;1851(4):433-45
pubmed: 25449649