Differential genome-wide DNA methylation patterns in childhood obesity.
Genome-wide DNA methylation
Immune function
Obesity
Prenatal maternal stress
Project Ice Storm
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
25 Mar 2019
25 Mar 2019
Historique:
received:
22
11
2018
accepted:
13
03
2019
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
23
7
2019
Statut:
epublish
Résumé
Exposure to stress during pregnancy may program susceptibility to the development of obesity in offspring. Our goal was to determine whether prenatal maternal stress (PNMS) due to a natural disaster was associated with child obesity, and to compare the DNA methylation profiles in obese versus non-obese children at age 13½ years. Women and their children were involved in the longitudinal natural disaster study-Project Ice Strom, which served as a human model to study PNMS. Blood was collected from 31 children (including five obese children). Infinium HumanMethylation450 BeadChip Array was performed for genome-wide DNA methylation analyses. Results demonstrated a well-defined obesity-associated genome-wide DNA methylation pattern. There were 277 CpGs, corresponding to 143 genes, were differentially-methylated. IPA analyses revealed 51 canonical pathways, and enrichment of pathways was involved in immune function. Although no significant association was found between PNMS and child obesity, the preliminary data in the study revealed obesity-associated methylation patterns on a genome-wide level in children.
Identifiants
pubmed: 30909978
doi: 10.1186/s13104-019-4189-0
pii: 10.1186/s13104-019-4189-0
pmc: PMC6434834
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
174Subventions
Organisme : CIHR Skin Research Training Centre
ID : MOP-1150067
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