Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism.

Animals Apoptosis / physiology Astrocytes / cytology Cell Movement / genetics Cell Proliferation / genetics Hypoxia-Inducible Factor-Proline Dioxygenases / genetics Mice Oxygen / metabolism Pseudopodia / metabolism Retina / cytology Vascular Endothelial Growth Factor A / metabolism
Angiogenesis Hypoxia PHD2 Retinal astrocytes Vascular pruning

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
17 04 2019
Historique:
received: 19 12 2018
accepted: 18 03 2019
pubmed: 27 3 2019
medline: 10 3 2020
entrez: 27 3 2019
Statut: epublish

Résumé

Vascular pruning is crucial for normal development, but its underlying mechanisms are poorly understood. Here, we report that retinal vascular pruning is controlled by the oxygen-sensing mechanism in local astrocytes. Oxygen sensing is mediated by prolyl hydroxylase domain proteins (PHDs), which use O

Identifiants

DOI: 10.1242/dev.175117 PMID: 30910827 PMC: PMC6503987
pubmed: 30910827
pii: dev.175117
doi: 10.1242/dev.175117
pmc: PMC6503987
pii:
doi:

Substances chimiques

Vascular Endothelial Growth Factor A 0
Egln1 protein, mouse EC 1.14.11.29
Hypoxia-Inducible Factor-Proline Dioxygenases EC 1.14.11.29
Oxygen S88TT14065

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NEI NIH HHS
ID : R01 EY019721
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031593
Pays : United States

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Références

Invest Ophthalmol Vis Sci. 2002 Feb;43(2):522-7
pubmed: 11818400
Glia. 2009 Jan 1;57(1):39-53
pubmed: 18661555
Circulation. 2012 Jun 26;125(25):3142-58
pubmed: 22661514
Nat Protoc. 2009;4(11):1565-73
pubmed: 19816419
Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2367-75
pubmed: 8933753
J Comp Neurol. 1987 Jan 1;255(1):35-49
pubmed: 3819008
Nat Cell Biol. 2014 Apr;16(4):309-21
pubmed: 24658686
Cell. 2001 Oct 5;107(1):43-54
pubmed: 11595184
Invest Ophthalmol Vis Sci. 1994 Jan;35(1):101-11
pubmed: 7507904
Nature. 2010 May 27;465(7297):487-91
pubmed: 20445540
Science. 2001 Nov 9;294(5545):1337-40
pubmed: 11598268
Dev Biol. 2012 Mar 1;363(1):106-14
pubmed: 22226979
Development. 1993 Jun;118(2):539-52
pubmed: 8223278
Blood. 2012 Aug 16;120(7):1516-27
pubmed: 22740442
Mol Vis. 2005 Aug 22;11:613-24
pubmed: 16148882
Nat Cell Biol. 2010 Oct;12(10):943-53
pubmed: 20871601
Nature. 1999 May 20;399(6733):271-5
pubmed: 10353251
Elife. 2016 Dec 22;5:
pubmed: 28005008
Genesis. 2001 Oct;31(2):85-94
pubmed: 11668683
Dev Cell. 2011 Aug 16;21(2):189-90
pubmed: 21839915
Am J Pathol. 2011 Apr;178(4):1881-90
pubmed: 21435465
J Cell Biol. 2003 Jun 23;161(6):1163-77
pubmed: 12810700
Nat Cell Biol. 2017 Aug;19(8):915-927
pubmed: 28714968
Development. 2014 Apr;141(8):1757-66
pubmed: 24715464
Sci Rep. 2017 Dec 14;7(1):17608
pubmed: 29242645
Nat Cell Biol. 2011 Sep 11;13(10):1202-13
pubmed: 21909098
Development. 2012 Apr;139(7):1327-35
pubmed: 22357924
Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3500-10
pubmed: 12407162
PLoS One. 2014 Jan 27;9(1):e84736
pubmed: 24475033
Mol Cell Biol. 2006 Nov;26(22):8336-46
pubmed: 16966370
Angiogenesis. 2007;10(2):77-88
pubmed: 17322966
Nat Med. 2003 Jun;9(6):781-8
pubmed: 12730690
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64
pubmed: 12351678
J Biol Chem. 2002 Nov 1;277(44):41750-5
pubmed: 12205091
Development. 2013 Jul;140(14):3051-61
pubmed: 23785053
Dev Cell. 2009 Jan;16(1):70-82
pubmed: 19154719
Nat Cell Biol. 2016 Dec;18(12):1292-1301
pubmed: 27870831
Int J Dev Neurosci. 2009 Nov;27(7):685-90
pubmed: 19646521
J Comp Neurol. 1989 Aug 15;286(3):345-52
pubmed: 2768562
Development. 2005 Apr;132(8):1855-62
pubmed: 15790963
PLoS One. 2013 Dec 23;8(12):e83049
pubmed: 24376630
J Neurosci. 2004 Sep 15;24(37):8124-34
pubmed: 15371513
PLoS One. 2010 Jul 29;5(7):e11863
pubmed: 20686684
J Neurocytol. 1992 Jul;21(7):530-44
pubmed: 1500949
Development. 2016 Aug 15;143(16):2973-82
pubmed: 27471260
Nature. 2007 Feb 15;445(7129):776-80
pubmed: 17259973
J Clin Invest. 2006 Feb;116(2):369-77
pubmed: 16424942
PLoS One. 2015 Oct 07;10(10):e0139994
pubmed: 26444547
JCI Insight. 2018 Feb 22;3(4):
pubmed: 29467323

Auteurs

Li-Juan Duan (LJ)

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA.

Guo-Hua Fong (GH)

Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA fong@uchc.edu.
Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA.
ORCID: 0000-0001-5792-6486

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Prolyl hydroxylases › Hypoxia-inducible factor-proline dioxygenases › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Pseudopodes › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Developmental vascular pruning in neonatal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Developmental vascular pruning in neonatal...