Reversing resistance to counter antimicrobial resistance in the World Health Organisation's critical priority of most dangerous pathogens.
antibiotic resistance
antibiotics
efflux pump inhibitor
membrane permeability
reversal of resistance
synergism
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
23
01
2019
revised:
18
03
2019
accepted:
22
03
2019
pubmed:
27
3
2019
medline:
14
4
2020
entrez:
27
3
2019
Statut:
epublish
Résumé
The speed at which bacteria develop antimicrobial resistance far outpace drug discovery and development efforts resulting in untreatable infections. The World Health Organisation recently released a list of pathogens in urgent need for the development of new antimicrobials. The organisms that are listed as the most critical priority are all Gram-negative bacteria resistant to the carbapenem class of antibiotics. Carbapenem resistance in these organisms is typified by intrinsic resistance due to the expression of antibiotic efflux pumps and the permeability barrier presented by the outer membrane, as well as by acquired resistance due to the acquisition of enzymes able to degrade β-lactam antibiotics. In this perspective article we argue the case for reversing resistance by targeting these resistance mechanisms - to increase our arsenal of available antibiotics and drastically reduce antibiotic discovery times - as the most effective way to combat antimicrobial resistance in these high priority pathogens.
Identifiants
pubmed: 30910848
pii: BSR20180474
doi: 10.1042/BSR20180474
pmc: PMC6465202
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Author(s).
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