The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.
Amino Acid Motifs
Antigens, CD
/ chemistry
Antigens, Differentiation, Myelomonocytic
/ chemistry
Escherichia coli
/ enzymology
Escherichia coli Proteins
/ chemistry
Humans
Lectins
/ chemistry
Mass Spectrometry
Metalloendopeptidases
/ chemistry
Mucins
/ chemistry
Neoplasm Proteins
/ chemistry
Sialic Acid Binding Immunoglobulin-like Lectins
/ chemistry
Substrate Specificity
O-glycosylation
Siglec
glycoproteomics
mucin
protease
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
pubmed:
27
3
2019
medline:
23
5
2019
entrez:
27
3
2019
Statut:
ppublish
Résumé
Mucin domains are densely
Identifiants
pubmed: 30910957
pii: 1813020116
doi: 10.1073/pnas.1813020116
pmc: PMC6462054
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
Escherichia coli Proteins
0
Lectins
0
Mucins
0
Neoplasm Proteins
0
SIGLEC7 protein, human
0
SIGLEC9 protein, human
0
Sialic Acid Binding Immunoglobulin-like Lectins
0
Metalloendopeptidases
EC 3.4.24.-
StcE protein, E coli
EC 3.4.24.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
7278-7287Subventions
Organisme : NCI NIH HHS
ID : R01 CA227942
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM059907
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM120007
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA221244
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest statement: A patent application relating to the use of enzymes to digest mucin-domain glycoproteins has been filed by Stanford University (docket no. STAN-1510PRV). C.R.B. is a cofounder and Scientific Advisory Board member of Palleon Pharmaceuticals, Enable Bioscience, Redwood Biosciences (a subsidiary of Catalent), and InterVenn Biosciences, and a member of the Board of Directors of Eli Lilly & Company. O.D. has participated in advisory boards for Tesaro, Merck, and Geneos. O.D. is a speaker for Tesaro and AstraZeneca.
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