Structural comparison of the vacuolar and Golgi V-ATPases from

STV1 V-ATPase VPH1 cryo-EM membrane protein

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
09 04 2019
Historique:
pubmed: 27 3 2019
medline: 27 3 2019
entrez: 27 3 2019
Statut: ppublish

Résumé

Proton-translocating vacuolar-type ATPases (V-ATPases) are necessary for numerous processes in eukaryotic cells, including receptor-mediated endocytosis, protein maturation, and lysosomal acidification. In mammals, V-ATPase subunit isoforms are differentially targeted to various intracellular compartments or tissues, but how these subunit isoforms influence enzyme activity is not clear. In the yeast

Identifiants

pubmed: 30910982
pii: 1814818116
doi: 10.1073/pnas.1814818116
pmc: PMC6462096
doi:

Banques de données

PDB
['6O7T', '6O7X']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

7272-7277

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : CIHR
ID : MOP81294
Pays : Canada
Organisme : Wellcome Trust
ID : 104633/Z/14/Z
Pays : United Kingdom

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Thamiya Vasanthakumar (T)

Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.

Stephanie A Bueler (SA)

Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

Di Wu (D)

Physical and Theoretical Chemistry Laboratory, University of Oxford, OX1 3QZ Oxford, United Kingdom.

Victoria Beilsten-Edmands (V)

Physical and Theoretical Chemistry Laboratory, University of Oxford, OX1 3QZ Oxford, United Kingdom.

Carol V Robinson (CV)

Physical and Theoretical Chemistry Laboratory, University of Oxford, OX1 3QZ Oxford, United Kingdom.

John L Rubinstein (JL)

Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; john.rubinstein@utoronto.ca.
Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.

Classifications MeSH