Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 03 2019
25 03 2019
Historique:
received:
31
12
2018
accepted:
14
03
2019
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has self-regulatory mechanisms in response to density stress. Only recently has this process begun to be acknowledged and characteristics of a programmed cell death been assigned to the parasite at high parasitaemia in vitro cultures. In searching for death signals within the parasite community, we have found that extracellular vesicles (EVs) of P. falciparum from high parasitaemia cultures are able to induce programmed cell death processes in the population. A comparative proteomic analysis of EVs from low (EV
Identifiants
pubmed: 30911042
doi: 10.1038/s41598-019-41697-x
pii: 10.1038/s41598-019-41697-x
pmc: PMC6434017
doi:
Substances chimiques
Protozoan Proteins
0
L-Lactate Dehydrogenase
EC 1.1.1.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5042Commentaires et corrections
Type : ErratumIn
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