New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in Tumoral and Non-Tumoral Breast Cells.
breast
cell cycle
fatty acid transport
fatty acid transport protein 6 (FATP6)
proliferation
solute carrier family 27 member 6 (SLC27A6)
very long-chain acyl-CoA synthetases member 2 (ACSVL2)
Journal
International journal of medical sciences
ISSN: 1449-1907
Titre abrégé: Int J Med Sci
Pays: Australia
ID NLM: 101213954
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
09
2018
accepted:
17
12
2018
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
25
7
2019
Statut:
epublish
Résumé
Long-chain fatty acids are the most abundant fatty acids and are essential for various physiological processes. Translocation of long-chain fatty acids across cell membrane is dependent on transport proteins. Solute carrier family 27 member 6 (SLC27A6) is a transport protein which mediates long-chain fatty acid uptake. The bioinformatic analysis revealed that the expression of SLC27A6 in non-tumoral breast tissue was higher than that in tumoral breast cancer in clinic samples. When SLC27A6 expression in non-tumorigenic cell H184B5F5/M10 was repressed, the fatty acids uptake capacity and cell proliferation was inhibited, and cell cycle was delayed. The protein expression of cell cycle regulators including cell division protein kinase 4 (CDK4), CDK6, and cyclin D1 was significantly decreased in SLC27A6-silenced H184B5F5/M10. By contrast, relatively low SLC27A6 expression in tumorigenic breast cancer cell Hs578T when compared to H184B5F5/M10. Repressing SLC27A6 expression did not affect these phenotypes in Hs578T. The interaction network of SLC27A6 was further investigated via STRING database. The function of these SLC27A6-associated proteins mainly involved in lipid biosynthesis, fatty acid metabolic process, and fatty acid transport. In conclusion, this study reveals inverse correlation between SLC27A6 expression and tumoral tissues and provides a new insight into SLC27A6-mediated cell growth and cell cycle regulation in non-tumorigenic breast cells.
Identifiants
pubmed: 30911270
doi: 10.7150/ijms.29946
pii: ijmsv16p0366
pmc: PMC6428986
doi:
Substances chimiques
Fatty Acid Transport Proteins
0
Fatty Acids
0
SLC27A6 protein, human
0
Types de publication
Journal Article
Langues
eng
Pagination
366-375Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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