HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells.
Animals
Cell Survival
/ drug effects
Cytokines
/ metabolism
Glucose
/ metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Infarction, Middle Cerebral Artery
/ drug therapy
Male
Microglia
/ drug effects
Neurons
/ drug effects
Oxygen
/ metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
04
2018
revised:
03
10
2018
accepted:
22
10
2018
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
14
5
2019
Statut:
epublish
Résumé
Ischemic stroke is usually followed by inflammatory responses mediated by microglia. However, the effect of statins on directly preventing posthypoxia microglia inflammatory factors to prevent injury to surrounding healthy neurons is unclear. Atorvastatin and rosuvastatin, which have different physical properties regarding their lipid and water solubility, are the most common HMG-CoA reductase inhibitors (statins) and might directly block posthypoxia microglia inflammatory factors to prevent injury to surrounding neurons. Neuronal damage and microglial activation of the peri-infarct areas were investigated by Western blotting and immunofluorescence after 24 hours in a middle cerebral artery occlusion (MCAO) rat model. The decrease in neurons was in accordance with the increase in microglia, which could be reversed by both atorvastatin and rosuvastatin. The effects of statins on blocking secretions from posthypoxia microglia and reducing the secondary damage to surrounding normal neurons were studied in a coculture system
Identifiants
pubmed: 30911291
doi: 10.1155/2019/7675496
pmc: PMC6397982
doi:
Substances chimiques
Cytokines
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Glucose
IY9XDZ35W2
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7675496Références
PLoS One. 2018 Feb 14;13(2):e0191909
pubmed: 29444171
J Asian Nat Prod Res. 2015;17(9):930-45
pubmed: 25971787
J Stroke. 2015 Sep;17(3):282-301
pubmed: 26437994
J Neural Transm (Vienna). 2015 Aug;122 Suppl 1:S47-54
pubmed: 24337666
Br J Pharmacol. 2015 Nov;172(22):5390-402
pubmed: 26362823
Hum Mol Genet. 2016 Dec 1;25(23):5148-5166
pubmed: 27677309
J Neurochem. 2006 Apr;97(1):140-50
pubmed: 16515553
Neurology. 2016 Mar 22;86(12):1103-11
pubmed: 26911636
J Neurochem. 2009 Feb;108(4):1045-56
pubmed: 19196431
J Neurochem. 2005 Mar;92(6):1386-98
pubmed: 15748157
J Neuroinflammation. 2016 Sep 02;13(1):234
pubmed: 27590054
Int J Stroke. 2017 Apr;12(3):302-320
pubmed: 28381199
J Neurosci. 2010 Aug 25;30(34):11414-25
pubmed: 20739563
J Cereb Blood Flow Metab. 2000 Mar;20(3):592-603
pubmed: 10724123
Sci Rep. 2016 May 31;6:26859
pubmed: 27240461
Int J Mol Sci. 2017 Oct 13;18(10):
pubmed: 29027964
PLoS One. 2016 Jun 16;11(6):e0157483
pubmed: 27309956
EMBO Mol Med. 2015 Jan 23;7(2):190-210
pubmed: 25617315
J Lipid Res. 2006 Oct;47(10):2148-60
pubmed: 16835442
Stroke. 2013 Mar;44(3):870-947
pubmed: 23370205
Nat Med. 2011 Jul 07;17(7):796-808
pubmed: 21738161
J Neurosci. 2014 Jun 25;34(26):8749-60
pubmed: 24966375
Neuropharmacology. 2007 Jan;52(1):136-45
pubmed: 16920163
Brain Sci. 2016 Feb 17;6(1):
pubmed: 26901230
Front Cell Neurosci. 2018 Aug 02;12:225
pubmed: 30116175
Stroke. 2017 Nov;48(11):2922-2923
pubmed: 29030475
Neuroscience. 2014 Mar 28;263:130-7
pubmed: 24440753
J Neuroinflammation. 2018 Mar 14;15(1):78
pubmed: 29540209
Am J Physiol Cell Physiol. 2009 Jan;296(1):C97-105
pubmed: 18971391
Neuroreport. 2014 Oct 1;25(14):1122-8
pubmed: 25089804
Prog Neurobiol. 1998 Oct;56(2):149-71
pubmed: 9760699
J Neuroinflammation. 2018 Mar 29;15(1):100
pubmed: 29598822
J Orthop Surg Res. 2017 Feb 27;12(1):36
pubmed: 28241838
Atherosclerosis. 2008 Sep;200(1):109-14
pubmed: 18261733
J Neurochem. 2012 Jul;122(2):233-43
pubmed: 22548274
Pharmacol Ther. 2015 Feb;146:23-34
pubmed: 25196155
Ther Adv Neurol Disord. 2018 May 22;11:1756286418774254
pubmed: 29854002
PLoS One. 2015 Dec 01;10(12):e0143686
pubmed: 26625143
PLoS One. 2014 May 12;9(5):e96509
pubmed: 24818601
Stroke. 2002 Sep;33(9):2254-60
pubmed: 12215596
Nature. 2016 Apr 14;532(7598):185-6
pubmed: 27049948
Metab Brain Dis. 2017 Aug;32(4):949-965
pubmed: 28578514
Brain Res. 2015 Dec 10;1629:231-9
pubmed: 26597376
BMC Neurol. 2017 Nov 23;17(1):203
pubmed: 29169331
Mol Med Rep. 2016 Nov;14(5):4055-4062
pubmed: 27633957
Mol Immunol. 2018 Mar;95:39-46
pubmed: 29407575
J Control Release. 2016 Mar 28;226:1-14
pubmed: 26836197
J Neuroimmune Pharmacol. 2017 Mar;12(1):152-162
pubmed: 27614888
Oncotarget. 2017 Oct 4;8(52):90176-90184
pubmed: 29163819
Brain Res Mol Brain Res. 1998 Jun 1;57(1):1-9
pubmed: 9630473
Expert Rev Neurother. 2009 Aug;9(8):1201-17
pubmed: 19673608
Neurotherapeutics. 2018 Apr;15(2):511-524
pubmed: 29110213
Stroke. 2017 Oct;48(10):2723-2730
pubmed: 28916672
Trends Immunol. 2008 Aug;29(8):357-65
pubmed: 18599350
J Neurochem. 2008 Jul;106(1):475-85
pubmed: 18410513
Stroke. 2010 Oct;41(10 Suppl):S144-6
pubmed: 20876491
Cytotherapy. 2016 Jun;18(6):771-84
pubmed: 27067610
J Stroke Cerebrovasc Dis. 2018 Jun;27(6):1697-1704
pubmed: 29525080
J Mol Neurosci. 2017 Jan;61(1):32-41
pubmed: 27541018
Intern Emerg Med. 2017 Aug;12(5):679-687
pubmed: 28303440
Neurochem Int. 2013 Jan;62(1):84-91
pubmed: 23201339
J Stroke Cerebrovasc Dis. 2017 Feb;26(2):352-359
pubmed: 27793535
J Neuroinflammation. 2012 Sep 06;9:211
pubmed: 22950459
Science. 1986 Apr 4;232(4746):34-47
pubmed: 3513311
Cereb Cortex. 2018 Jul 1;28(7):2622-2635
pubmed: 29746630
Neural Plast. 2015;2015:374520
pubmed: 26448879
Oxid Med Cell Longev. 2013;2013:906726
pubmed: 23983903
PLoS One. 2011;6(7):e21880
pubmed: 21755005
J Neurochem. 2004 Apr;89(1):24-32
pubmed: 15030386
J Neurosci. 2008 Feb 13;28(7):1649-58
pubmed: 18272685
Curr Med Chem. 2014;21(19):2146-55
pubmed: 24372213
Cell Mol Neurobiol. 2017 May;37(4):753-762
pubmed: 27488855
Sci Rep. 2016 Jul 26;6:30459
pubmed: 27456198
J Neural Transm (Vienna). 2010 Aug;117(8):919-47
pubmed: 20632195