A Case-Control Study on Risk Factors and Their Interactions with Prediabetes among the Elderly in Rural Communities of Yiyang City, Hunan Province.
Aged
Aged, 80 and over
Case-Control Studies
China
/ epidemiology
Exercise
Female
Glucose Tolerance Test
Health Literacy
Humans
Hypertension
/ complications
Life Style
Male
Middle Aged
Overweight
/ complications
Prediabetic State
/ diagnosis
Prevalence
Risk Factors
Rural Population
Surveys and Questionnaires
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
09
2018
revised:
15
01
2019
accepted:
29
01
2019
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
28
7
2019
Statut:
epublish
Résumé
The prevalence of prediabetes has been increasing significantly in recent years. Individuals with prediabetes have an increased risk of developing diabetes and cardiovascular diseases. The objectives of this study were to identify risk factors for prediabetes and their interactions among the elderly in rural communities of Hunan Province and to provide a scientific basis for prediabetes prevention. A case-control study was conducted to explore risk factors for prediabetes among the elderly in rural areas. The general sociodemographic information, lifestyle behaviours, and physiological results of elderly individuals with prediabetes and controls were collected by a questionnaire and laboratory testing. Conditional logistic regression was performed to identify the risk factors for prediabetes among the elderly, and additive interactions were used to analyse the interactions between risk factors. A total of 425 elderly subjects with prediabetes were included in the case group, and 425 elderly subjects with normal plasma glucose levels were included in the control group. The main risk factors for prediabetes among the elderly in rural communities of Hunan Province were a family history of diabetes (OR = 2.48; 95% CI: 1.13, 5.46), physical inactivity (OR = 3.27; 95% CI: 1.95, 5.49), a lack of health literacy on diabetes prevention and control (OR = 3.26; 95% CI: 1.62, 6.55), hypertension (OR = 2.01; 95% CI: 1.38, 2.93), overweight (OR = 2.53; 95% CI: 1.67, 3.81), obesity (OR = 3.08; 95% CI: 1.48, 6.40), and a high waist-to-hip ratio (WHR) (OR = 2.26; 95% CI: 1.45, 3.51). Additive interactions for prediabetes were detected between a high WHR and physical inactivity, with a relative excess risk due to interaction (RERI) of 6.30 (95% CI: 0.42, 12.18), and between a high WHR and overweight or obesity, with an RERI of 2.92 (95% CI: 0.56, 5.29). The independent risk factors for prediabetes are a family history of diabetes, physical inactivity, a lack of health literacy on diabetes prevention and control, hypertension, overweight or obesity, and a high WHR. A high WHR has additive interactions with physical inactivity and overweight or obesity for the risk of prediabetes. These findings have significant implications for prediabetes prevention among the elderly in rural areas.
Sections du résumé
BACKGROUND
BACKGROUND
The prevalence of prediabetes has been increasing significantly in recent years. Individuals with prediabetes have an increased risk of developing diabetes and cardiovascular diseases. The objectives of this study were to identify risk factors for prediabetes and their interactions among the elderly in rural communities of Hunan Province and to provide a scientific basis for prediabetes prevention.
METHODS
METHODS
A case-control study was conducted to explore risk factors for prediabetes among the elderly in rural areas. The general sociodemographic information, lifestyle behaviours, and physiological results of elderly individuals with prediabetes and controls were collected by a questionnaire and laboratory testing. Conditional logistic regression was performed to identify the risk factors for prediabetes among the elderly, and additive interactions were used to analyse the interactions between risk factors.
RESULTS
RESULTS
A total of 425 elderly subjects with prediabetes were included in the case group, and 425 elderly subjects with normal plasma glucose levels were included in the control group. The main risk factors for prediabetes among the elderly in rural communities of Hunan Province were a family history of diabetes (OR = 2.48; 95% CI: 1.13, 5.46), physical inactivity (OR = 3.27; 95% CI: 1.95, 5.49), a lack of health literacy on diabetes prevention and control (OR = 3.26; 95% CI: 1.62, 6.55), hypertension (OR = 2.01; 95% CI: 1.38, 2.93), overweight (OR = 2.53; 95% CI: 1.67, 3.81), obesity (OR = 3.08; 95% CI: 1.48, 6.40), and a high waist-to-hip ratio (WHR) (OR = 2.26; 95% CI: 1.45, 3.51). Additive interactions for prediabetes were detected between a high WHR and physical inactivity, with a relative excess risk due to interaction (RERI) of 6.30 (95% CI: 0.42, 12.18), and between a high WHR and overweight or obesity, with an RERI of 2.92 (95% CI: 0.56, 5.29).
CONCLUSION
CONCLUSIONS
The independent risk factors for prediabetes are a family history of diabetes, physical inactivity, a lack of health literacy on diabetes prevention and control, hypertension, overweight or obesity, and a high WHR. A high WHR has additive interactions with physical inactivity and overweight or obesity for the risk of prediabetes. These findings have significant implications for prediabetes prevention among the elderly in rural areas.
Identifiants
pubmed: 30911549
doi: 10.1155/2019/1386048
pmc: PMC6398036
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1386048Références
J Pediatr. 1999 Sep;135(3):301-6
pubmed: 10484793
JAMA. 2002 Jul 24-31;288(4):475-82
pubmed: 12132978
Diabetes. 2003 Jan;52(1):102-10
pubmed: 12502499
Diabetes Care. 2003 Jan;26(1):48-54
pubmed: 12502657
JAMA. 2003 Apr 9;289(14):1785-91
pubmed: 12684356
Diabet Med. 2004 Feb;21(2):188-93
pubmed: 14984456
Int J Obes Relat Metab Disord. 2004 May;28(5):710-8
pubmed: 15007395
Metabolism. 2004 Apr;53(4):454-7
pubmed: 15045691
Am J Prev Med. 2004 Aug;27(2):87-96
pubmed: 15261894
Eur Heart J. 2004 Nov;25(21):1880-90
pubmed: 15522466
Obes Rev. 2005 May;6(2):123-32
pubmed: 15836463
J Appl Physiol (1985). 2005 Sep;99(3):1205-13
pubmed: 16103523
Eur J Epidemiol. 2005;20(7):575-9
pubmed: 16119429
BMJ. 2006 May 6;332(7549):1064-9
pubmed: 16603565
BMJ. 2006 Aug 19;333(7564):362-3
pubmed: 16916811
Diabetologia. 2006 Nov;49(11):2589-98
pubmed: 16969647
J Nutr. 2006 Nov;136(11):2908-15
pubmed: 17056821
Diabetes Care. 2007 Feb;30(2):228-33
pubmed: 17259486
Am Heart J. 2007 Apr;153(4):552-8
pubmed: 17383293
Eur Heart J. 2007 Dec;28(23):2937-43
pubmed: 17925342
Vasc Health Risk Manag. 2007;3(4):511-20
pubmed: 17969381
Diabetologia. 2008 Feb;51(2):249-57
pubmed: 18060659
J Hypertens. 2008 Feb;26(2):169-77
pubmed: 18192826
Lancet. 2008 May 24;371(9626):1783-9
pubmed: 18502303
Med Clin North Am. 2011 Mar;95(2):327-39, vii-viii
pubmed: 21281836
J Diabetes. 2011 Jun;3(2):138-46
pubmed: 21599867
Diabetologia. 2011 Dec;54(12):3022-7
pubmed: 21959957
Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Jul;39(7):579-615
pubmed: 22088239
Lancet. 2012 Jun 16;379(9833):2279-90
pubmed: 22683128
Diabetes Care. 2013 Mar;36(3):729-33
pubmed: 23223344
Diabet Med. 2013 Oct;30(10):1198-203
pubmed: 23659572
Diabetologia. 2013 Oct;56(10):2176-80
pubmed: 23979484
JAMA. 2013 Sep 4;310(9):948-59
pubmed: 24002281
Obes Rev. 2014 Jan;15 Suppl 1:2-7
pubmed: 24341753
BMJ Open. 2014 Mar 13;4(3):e004436
pubmed: 24625639
Ann Med. 2014 Dec;46(8):684-92
pubmed: 25230915
Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Jul;48(7):561-5
pubmed: 25312561
Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Aug;35(8):961-4
pubmed: 25376692
Diabetes Metab. 2015 Apr;41(2):160-7
pubmed: 25451187
J Formos Med Assoc. 2015 Dec;114(12):1233-9
pubmed: 25604720
BMC Fam Pract. 2015 Jan 22;16:5
pubmed: 25609029
Int J Environ Res Public Health. 2015 Oct 12;12(10):12662-78
pubmed: 26473900
Diabetes Res Clin Pract. 2015 Dec;110(3):241-9
pubmed: 26520567
PLoS One. 2015 Dec 29;10(12):e0145781
pubmed: 26714019
BMJ Open. 2016 May 27;6(5):e011077
pubmed: 27235299
Int J Environ Res Public Health. 2016 Aug 10;13(8):
pubmed: 27517947
BMJ. 2016 Nov 23;355:i5953
pubmed: 27881363
Neuropsychiatr Dis Treat. 2017 Feb 02;13:259-267
pubmed: 28203079
Int J Equity Health. 2017 Jul 1;16(1):58
pubmed: 28666443
BMC Res Notes. 2017 Jul 6;10(1):251
pubmed: 28683811
Int J Environ Res Public Health. 2017 Oct 10;14(10):
pubmed: 28994716
Sleep Health. 2015 Dec;1(4):233-243
pubmed: 29073398
Public Health. 2018 Mar;156:8-14
pubmed: 29353668
J Geriatr Cardiol. 2018 Jan;15(1):1-29
pubmed: 29434622
Diabetes Care. 1993 Nov;16(11):1494-501
pubmed: 8299439
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693