Promoting healthspan and lifespan with caloric restriction in primates.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
2019
Historique:
received: 05 02 2019
accepted: 06 02 2019
entrez: 27 3 2019
pubmed: 27 3 2019
medline: 27 3 2019
Statut: epublish

Résumé

Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.

Identifiants

pubmed: 30911682
doi: 10.1038/s42003-019-0348-z
pii: 348
pmc: PMC6420603
doi:

Types de publication

Journal Article

Langues

eng

Pagination

107

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Fabien Pifferi (F)

UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.

Jérémy Terrien (J)

UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.

Martine Perret (M)

UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.

Jacques Epelbaum (J)

UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.
2Unité Mixte de Recherche en Santé 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.

Stéphane Blanc (S)

3Université de Strasbourg, IPHC, 23 rue Becquerel, 67087 Strasbourg, France.
4CNRS, UMR7178, 67087 Strasbourg, France.

Jean-Luc Picq (JL)

5Laboratoire de psychopathologie et de neuropsychologie, E.A. 2027, Université Paris 8, 2 rue de la liberté, 93000 St. Denis, France.
CNRS, CEA, Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, 92265 Fontenay-aux-Roses, France.
Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Molecular Imaging Research Center (MIRCen), 92265 Fontenay-aux-Roses, France.

Marc Dhenain (M)

CNRS, CEA, Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, 92265 Fontenay-aux-Roses, France.
Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Molecular Imaging Research Center (MIRCen), 92265 Fontenay-aux-Roses, France.

Fabienne Aujard (F)

UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.

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Classifications MeSH