Taurine-upregulated gene 1: A functional long noncoding RNA in tumorigenesis.
TUG1
cancer
lncRNA
taurine-upregulated gene 1
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
22
12
2018
revised:
02
02
2019
accepted:
19
02
2019
pubmed:
27
3
2019
medline:
27
5
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
Taurine-upregulated gene 1 (TUG1) is a 7.1 kb long noncoding RNA (lncRNA) first recognized in 2005 as an important element for retinal development in rodents. Subsequently, this lncRNA has been shown to participate in oncogenic processes through alteration in chromatin structure, sponging microRNAs, and affecting the expression of some cancer-related pathways. While most of the studies have revealed an oncogenic role for this lncRNA, some reports have shown downregulation of TUG1 in lung cancer samples compared with noncancerous samples. In triple negative breast cancer samples, the expression of this lncRNA has been decreased. Besides, its expression has been higher in HER2-enriched and basal-like subtypes compared with luminal A. In the current review, we discuss the latest literature about the expression pattern and functional roles of TUG1 in diverse cancer types. In addition, its role in epithelial-mesenchymal transition and activation of Wnt/β-catenin pathway in human malignancies will be explored.
Substances chimiques
RNA, Long Noncoding
0
TUG1 long noncoding RNA, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17100-17112Informations de copyright
© 2019 Wiley Periodicals, Inc.