Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease?
Eosinophils
epithelium
therapy
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
23
08
2018
revised:
10
10
2018
accepted:
14
10
2018
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
27
3
2019
Statut:
ppublish
Résumé
Eosinophils have long been recognized as a central effector cell in the lungs of asthmatic patients. They contribute to airway inflammation and remodeling through releasing several molecules such as cytokines, granule proteins, lipid mediators and extracellular traps/vesicles. Repeated evidence reveals that intense eosinophil infiltration in upper and lower airway mucosae contributes to the pathogenesis of aspirin-exacerbated respiratory disease (AERD). Persistent eosinophilia is found to be associated with type 2 immune responses, cysteinyl leukotriene overproduction and eosinophil-epithelium interactions. This review highlights recent findings about key mechanisms of eosinophil activation in the airway inflammation of AERD. In addition, current biologics (targeting type 2 immune responses) were suggested to control eosinophilic inflammation for AERD patients.
Identifiants
pubmed: 30912322
pii: 11.320
doi: 10.4168/aair.2019.11.3.320
pmc: PMC6439191
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
320-329Subventions
Organisme : Ministry of Health and Welfare
ID : HI16C0992
Pays : Korea
Informations de copyright
Copyright © 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
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