Synthesis and preliminary radiopharmacological characterisation of an

Animals Biological Transport Carbon Radioisotopes Cathepsins / metabolism Cell Line, Tumor Chemistry Techniques, Synthetic Cysteine / metabolism Dipeptides / chemistry Female Humans Mice Mice, Nude Nitriles / chemical synthesis Positron-Emission Tomography / methods Radioactive Tracers
carbon-11 cysteine cathepsins enzyme inhibitors molecular imaging pharmacokinetics radiosynthesis tumour-associated enzymes

Journal

Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344
Titre abrégé: J Labelled Comp Radiopharm
Pays: England
ID NLM: 7610510

Informations de publication

Date de publication:
30 06 2019
Historique:
received: 10 01 2019
revised: 04 03 2019
accepted: 15 03 2019
pubmed: 27 3 2019
medline: 29 4 2020
entrez: 27 3 2019
Statut: ppublish

Résumé

An O-methyltyrosine-containing azadipeptide nitrile was synthesised and investigated for its inhibitory activity towards cathepsins L, S, K, and B. Labelling with carbon-11 was accomplished by reaction of the corresponding phenolic precursor with [

Identifiants

DOI: 10.1002/jlcr.3729 PMID: 30912586
pubmed: 30912586
doi: 10.1002/jlcr.3729
doi:

Substances chimiques

Carbon Radioisotopes 0
Carbon-11 0
Dipeptides 0
Nitriles 0
Radioactive Tracers 0
Cathepsins EC 3.4.-
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

448-459

Informations de copyright

© 2019 John Wiley & Sons, Ltd.

Auteurs

Markus Laube (M)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Maxim Frizler (M)

Pharmaceutical Institute, Pharmaceutical Chemistry I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.

Robert Wodtke (R)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Christin Neuber (C)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Birgit Belter (B)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Torsten Kniess (T)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
ORCID: 0000-0002-4107-3455

Michael Bachmann (M)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
ORCID: 0000-0002-8029-5755

Michael Gütschow (M)

Pharmaceutical Institute, Pharmaceutical Chemistry I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.

Jens Pietzsch (J)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Dresden, Germany.

Reik Löser (R)

Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0003-1531-7601

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Métabolisme › Transport biologique › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Cathepsines › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Dipeptides › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Synthesis and preliminary radiopharmacological...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Traceurs radioactifs › Synthesis and preliminary radiopharmacological...