Subcutaneous adipose tissue distribution and telomere length.
BMI
leukocyte telomere length
obesity
subcutaneous adipose tissue distribution
Journal
Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Titre abrégé: Clin Chem Lab Med
Pays: Germany
ID NLM: 9806306
Informations de publication
Date de publication:
27 08 2019
27 08 2019
Historique:
received:
26
07
2018
accepted:
01
03
2019
pubmed:
27
3
2019
medline:
5
8
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
Background Overweight and obese individuals have a reduced life expectancy due to cardiovascular disease (CVD), type 2 diabetes, stroke and cancer. Systemic inflammation and premature telomere shortening have been discussed as potential mechanisms linking these conditions. We investigated the relation of subcutaneous adipose tissue (SAT) distribution to leukocyte relative telomere length (RTL). Methods We measured RTL in 375 participants of the observational STYJOBS/EDECTA cohort (ClinicalTrials.gov Identifier NCT00482924) using a qPCR based method. SAT distribution was determined by lipometry yielding a percent body fat value and SAT thicknesses at 15 standardized locations across the entire body. A correlation analysis between RTL, age, sex, lipometry data and conventional body measures (body mass index [BMI], waist-, hip circumference, waist-to-hip ratio, waist-to-height ratio) was calculated. The strongest determinants of RTL were determined by a stepwise multiple regression analysis. Results RTL was not associated with age or sex. RTL was significantly negatively correlated with BMI, percent body fat, waist-, hip circumference and waist-to-height ratio. Furthermore, RTL correlated with SAT at the following locations: neck, triceps, biceps, upper back, front chest, lateral chest, upper abdomen, lower abdomen, lower back, hip, front thigh, lateral thigh, rear thigh and calf. Stepwise regression analysis revealed nuchal and hip SAT as the strongest predictors of RTL. No significant association was seen between RTL and waist-to-hip ratio. Conclusions RTL is negatively associated with parameters describing body fat composure. Nuchal and hip SAT thicknesses are the strongest predictors of RTL. Central obesity appears to correlate with premature genomic aging.
Identifiants
pubmed: 30913032
doi: 10.1515/cclm-2018-0801
pii: cclm-2018-0801
doi:
Banques de données
ClinicalTrials.gov
['NCT00482924']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1358-1363Références
Maffetone PB, Rivera-Dominguez I, Laursen PB. Overfat and underfat: new terms and definitions long overdue. Front Pub Health 2016;4:279.
Tafeit E, Horejsi R, Pieber TR, Roller RE, Schnedl WJ, Wallner SJ, et al. Subcutaneous fat patterns in type-2 diabetic men and healthy controls. Coll Antropol 2008;32:607–14.
Mangge H, Almer G, Truschnig-Wilders M, Schmidt A, Gasser R, Fuchs D. Inflammation, adiponectin, obesity and cardiovascular risk. Curr Med Chem 2010;17:4511–20.
Bluher M. Fat tissue and long life. Obes Facts 2008;1:176–82.
Stohr BA, Xu L, Blackburn EH. The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. Mol Cell 2010;39:307–14.
Lakowa N, Trieu N, Flehmig G, Lohmann T, Schon MR, Dietrich A, et al. Telomere length differences between subcutaneous and visceral adipose tissue in humans. Biochem Biophys Res Commun 2015;457:426–32.
Park Y, Peterson LL, Colditz GA. The plausibility of obesity paradox in cancer-point. Cancer Res 2018;78:1898–903.
Hall ME. Body mass index and heart failure mortality: more is less? JACC Heart Fail 2018;6:243–5.
Abramowitz MK, Hall CB, Amodu A, Sharma D, Androga L, Hawkins M. Muscle mass, BMI, and mortality among adults in the United States: a population-based cohort study. PLoS One 2018;13:e0194697.
Revesz D, Milaneschi Y, Verhoeven JE, Lin J, Penninx BW. Longitudinal associations between metabolic syndrome components and telomere shortening. J Clin Endocrinol Metab 2015;100:3050–9.
Wulaningsih W, Kuh D, Wong A, Hardy R. Adiposity, telomere length, and telomere attrition in midlife: the 1946 British birth cohort. J Gerontol A Biol Sci Med Sci 2018;73:966–72.
Yang M, Jiang P, Jin C, Wang J. Longer telomere length and its association with lower levels of C-peptide. Front Endocrinol (Lausanne) 2017;8:244.
Batsis JA, Mackenzie TA, Vasquez E, Germain CM, Emeny RT,Rippberger P, et al. Association of adiposity, telomere length and mortality: data from the NHANES 1999–2002. Int J Obes (Lond) 2018;42:198–204.
Dershem R, Chu X, Wood GC, Benotti P, Still CD, Rolston DD. Changes in telomere length 3–5 years after gastric bypass surgery. Int J Obes (Lond) 2017;41:1718–20.
Iglesias Molli AE, Panero J, Dos Santos PC, Gonzalez CD, Vilarino J, Sereday M, et al. Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome. PLoS One 2017;12:e0174945.
Guzzardi MA, Iozzo P, Salonen MK, Kajantie E, Eriksson JG. Maternal adiposity and infancy growth predict later telomere length: a longitudinal cohort study. Int J Obes (Lond) 2016;40:1063–9.
Muezzinler A, Mons U, Dieffenbach AK, Butterbach K, Saum KU, Schick M, et al. Body mass index and leukocyte telomere length dynamics among older adults: results from the ESTHER cohort. Exp Gerontol 2016;74:1–8.
Mundstock E, Sarria EE, Zatti H, Mattos Louzada F, Kich Grun L, Herbert Jones M, et al. Effect of obesity on telomere length: systematic review and meta-analysis. Obesity 2015;23:2165–74.
Muezzinler A, Zaineddin AK, Brenner H. Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis. Obes Rev 2014;15:192–201.
Moller R, Tafeit E, Sudi K, Reibnegger G. Quantifying the ‘appleness’ or ‘pearness’ of the human body by subcutaneous adipose tissue distribution. Ann Hum Biol 2000;27:47–55.
Moeller R, Horejsi R, Pilz S, Lang N, Sargsyan K, Dimitrova R, et al. Evaluation of risk profiles by subcutaneous adipose tissue topography in obese juveniles. Obesity 2007;15:1319–24.
Moller R, Tafeit E, Pieber TR, Sudi K, Reibnegger G. Measurement of subcutaneous adipose tissue topography (SAT-Top) by means of a new optical device, LIPOMETER, and the evaluation of standard factor coefficients in healthy subjects. Am J Hum Biol 2000;12:231–9.
Cawthon RM. Telomere measurement by quantitative PCR. Nucl Acids Res 2002;30:e47.
Tzanetakou IP, Katsilambros NL, Benetos A, Mikhailidis DP,Perrea DN. “Is obesity linked to aging?”: adipose tissue and the role of telomeres. Ageing Res Rev 2012;11:220–9.
Dai Y, Wan X, Li X, Jin E, Li X. Neck circumference and future cardiovascular events in a high-risk population – a prospective cohort study. Lipids Health Dis 2016;15:46.
Koppad AK, Kaulgud RS, Arun BS. A study of correlation of neck circumference with Framingham risk score as a predictor of coronary artery disease. J Clin Diag Res 2017;11:OC17–20.
Wulaningsih W, Watkins J, Matsuguchi T, Hardy R. Investigating the associations between adiposity, life course overweight trajectories, and telomere length. Aging 2016;8:2689–701.
Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, et al. Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany, NY) 2014;6:380–9.
Zgheib NK, Sleiman F, Nasreddine L, Nasrallah M, Nakhoul N, Isma’eel H, et al. Short telomere length is associated with aging, central obesity, poor sleep and hypertension in Lebanese individuals. Aging Dis 2018;9:77–89.
Weghuber D, Zelzer S, Stelzer I, Paulmichl K, Kammerhofer D, Schnedl W, et al. High risk vs. “metabolically healthy” phenotype in juvenile obesity – neck subcutaneous adipose tissue and serum uric acid are clinically relevant. Exp Clin Endocrinol Diabet 2013;121:384–90.
Mangge H, Zelzer S, Puerstner P, Schnedl WJ, Reeves G, Postolache TT, et al. Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity 2013;21:E71–7.
Wallner-Liebmann SJ, Moeller R, Horejsi R, Jurimae T, Jurimae J, Maestu J, et al. Normal weight estonian prepubertal boys show a more cardiovascular-risk-associated adipose tissue distribution than austrian counterparts. ISRN Obes 2013;2013:506751.
Kadakia MB, Fox CS, Scirica BM, Murphy SA, Bonaca MP, Morrow DA. Central obesity and cardiovascular outcomes in patients with acute coronary syndrome: observations from the MERLIN-TIMI 36 trial. Heart 2011;97:1782–7.
Chen WZ, Chen XD, Ma LL, Zhang FM, Lin J, Zhuang CL, et al. Impact of visceral obesity and sarcopenia on short-term outcomes after colorectal cancer surgery. Dig Dis Sci 2018;63:1620–30.
Doyle SL, Mongan AM, Donohoe CL, Pidgeon GP, Sherlock M, Reynolds JV, et al. Impact of visceral obesity and metabolic syndrome on the postoperative immune, inflammatory, and endocrine response following surgery for esophageal adenocarcinoma. Dis Esophagus 2017;30:1–11.
Kuritzkes BA, Pappou EP, Kiran RP, Baser O, Fan L, Guo X, et al. Visceral fat area, not body mass index, predicts postoperative 30-day morbidity in patients undergoing colon resection for cancer. Int J Colorectal Dis 2018;8:1019–28.
Mangge H, Almer G, Haj-Yahya S, Grandits N, Gasser R, Pilz S, et al. Nuchal thickness of subcutaneous adipose tissue is tightly associated with an increased LMW/total adiponectin ratio in obese juveniles. Atherosclerosis 2009;203:277–83.
Mangge H, Becker K, Fuchs D, Gostner JM. Antioxidants, inflammation and cardiovascular disease. World J Cardiol 2014;6:462–77.
Mangge H, Schauenstein K, Stroedter L, Griesl A, Maerz W, Borkenstein M. Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis. Exp Clin Endocrinol Diabetes 2004;112:378–82.
Mangge H, Ciardi C, Becker K, Strasser B, Fuchs D, Gostner JM. Influence of antioxidants on leptin metabolism and its role in the pathogenesis of obesity. Adv Exp Med Biol 2017;960:399–413.
Wafa SW, Hamzaid H, Talib RA, Reilly JJ. Objectively measured habitual physical activity and sedentary behaviour in obese and non-obese Malaysian children. J Trop Pediatr 2014;60:161–3.
Werner C, Hanhoun M, Widmann T, Kazakov A, Semenov A, Poss J, et al. Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol 2008;52:470–82.
Ludlow AT, Gratidao L, Ludlow LW, Spangenburg EE, Roth SM. Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle. Exp Physiol 2017;102:397–410.
Martinez P, Gomez-Lopez G, Garcia F, Mercken E, Mitchell S, Flores JM, et al. RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Rep 2013;3:2059–74.
Yeung F, Ramirez CM, Mateos-Gomez PA, Pinzaru A, Ceccarini G, Kabir S, et al. Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity. Cell Rep 2013;3:1847–56.
Carulli L, Anzivino C, Baldelli E, Zenobii MF, Rocchi MB, Bertolotti M. Telomere length elongation after weight loss intervention in obese adults. Mol Genet Metab 2016;118:138–42.
Laimer M, Melmer A, Lamina C, Raschenberger J, Adamovski P, Engl J, et al. Telomere length increase after weight loss induced by bariatric surgery: results from a 10 year prospective study. Int J Obes (Lond) 2016;40:773–8.
Tafeit E, Moller R, Sudi K, Horejsi R, Berg A, Reibnegger G. Orthogonal factor coefficient development of subcutaneous adipose tissue topography (SAT-Top) in girls and boys. Am J Phys Anthropol 2001;115:57–61.
Moller R, Tafeit E, Smolle KH, Pieber TR, Ipsiroglu O, Duesse M, et al. Estimating percentage total body fat and determining subcutaneous adipose tissue distribution with a new noninvasive optical device LIPOMETER. Am J Hum Biol 2000;12:221–30.