Cytotoxic polyhydroxy serratene triterpenoids from Lycopodium complanatum.
Cytotoxic activities
Lycopodium complanatum
Polyhydroxy serratene triterpenoids
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
23
01
2019
revised:
27
02
2019
accepted:
05
03
2019
pubmed:
27
3
2019
medline:
23
9
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
Phytochemical investigation of the 70% aqueous EtOH extract of Lycopodium complanatum led to six new polyhydroxy serratene triterpenoids (serrat A-F, 1-6), along with a known analogue (7). Their structures and configurations were elucidated by data analysis of HRESIMS, 1D and 2D NMR, in combination with comparisons of reported experimental spectroscopic data. All the isolates were evaluated cytotoxic activities against HepG2 cells, MCF-7 cells and series human lung cancer cell lines A549, Calu-6, NCI-H441, NCI-H226 and NCI-H1975. The results indicated that certain compounds inhibited proliferation of human cancer cells. Moreover, all compounds possessed selective cytotoxic activities on MCF-7 cells. Further, possible biosynthesis pathways of these compounds were proposed.
Identifiants
pubmed: 30913469
pii: S0045-2068(19)30120-8
doi: 10.1016/j.bioorg.2019.03.011
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Triterpenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
373-379Informations de copyright
Copyright © 2019. Published by Elsevier Inc.