Using chemical inhibitors to probe AAA protein conformational dynamics and cellular functions.

AAA Proteins / chemistry Humans Molecular Probes Organelles / metabolism Pharmaceutical Preparations Protein Conformation

Journal

Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312

Informations de publication

Date de publication:
06 2019
Historique:
received: 20 11 2018
revised: 18 02 2019
accepted: 19 02 2019
pubmed: 27 3 2019
medline: 18 12 2019
entrez: 27 3 2019
Statut: ppublish

Résumé

The AAA proteins are a family of enzymes that play key roles in diverse dynamic cellular processes, ranging from proteostasis to directional intracellular transport. Dysregulation of AAA proteins has been linked to several diseases, including cancer, suggesting a possible therapeutic role for inhibitors of these enzymes. In the past decade, new chemical probes have been developed for AAA proteins including p97, dynein, midasin, and ClpC1. In this review, we discuss how these compounds have been used to study the cellular functions and conformational dynamics of AAA proteins. We discuss future directions for inhibitor development and early efforts to utilize AAA protein inhibitors in the clinical setting.

Identifiants

DOI: 10.1016/j.cbpa.2019.02.019 PMID: 30913482 PMC: PMC6880239
pubmed: 30913482
pii: S1367-5931(18)30185-6
doi: 10.1016/j.cbpa.2019.02.019
pmc: PMC6880239
mid: NIHMS1051133
pii:
doi:

Substances chimiques

Molecular Probes 0
Pharmaceutical Preparations 0
AAA Proteins EC 3.6.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-54

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM098579
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130234
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Références

Mol Microbiol. 2003 Apr;48(1):77-84
pubmed: 12657046
Nature. 2016 Nov 3;539(7627):48-53
pubmed: 27749819
Elife. 2017 May 19;6:
pubmed: 28524820
Cell Death Dis. 2018 Mar 14;9(3):402
pubmed: 29540729
J Biol Chem. 2014 Feb 14;289(7):3913-22
pubmed: 24371142
Biochem J. 2017 Aug 17;474(17):2953-2976
pubmed: 28819009
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4178-87
pubmed: 26195788
J Cell Biol. 2013 Sep 2;202(5):779-92
pubmed: 23979719
Nat Rev Mol Cell Biol. 2005 Jul;6(7):519-29
pubmed: 16072036
J Biol Chem. 2018 Jun 1;293(22):8379-8393
pubmed: 29632076
Nature. 2012 Mar 18;484(7392):125-9
pubmed: 22425997
Chem Rev. 2017 Jan 11;117(1):139-155
pubmed: 27622975
Chem Biol. 2014 Apr 24;21(4):509-518
pubmed: 24684906
FEBS J. 2017 Sep;284(18):2905-2931
pubmed: 28342295
ACS Chem Biol. 2016 Jan 15;11(1):53-60
pubmed: 26555042
Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5889-91
pubmed: 21563281
J Biol Chem. 2013 Oct 25;288(43):30883-91
pubmed: 24022489
Curr Opin Microbiol. 2017 Apr;36:118-127
pubmed: 28458096
Expert Opin Ther Targets. 2018 Jan;22(1):85-96
pubmed: 29148850
Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6
pubmed: 29396292
Oncotarget. 2017 Apr 18;8(16):26718-26731
pubmed: 28157697
Biochem Soc Trans. 2018 Aug 20;46(4):967-982
pubmed: 30065109
Biochem J. 2017 Jan 15;474(2):195-214
pubmed: 28062837
Traffic. 2007 Dec;8(12):1657-67
pubmed: 17897320
Nat Prod Rep. 2017 Jul 6;34(7):815-831
pubmed: 28375422
Cell. 2018 Oct 18;175(3):822-834.e18
pubmed: 30318141
ACS Chem Biol. 2019 Feb 15;14(2):236-244
pubmed: 30640450
Front Cell Neurosci. 2015 Jul 06;9:252
pubmed: 26217180
Front Mol Biosci. 2017 Jul 19;4:49
pubmed: 28770209
Microbiol Mol Biol Rev. 2016 Jan 13;80(1):139-60
pubmed: 26764017
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7
pubmed: 19666565
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9
pubmed: 21383145
Org Lett. 2014 Dec 5;16(23):6044-7
pubmed: 25409285
Science. 2016 Feb 19;351(6275):871-5
pubmed: 26822609
J Med Chem. 2016 Sep 22;59(18):8521-34
pubmed: 27536893
Nat Struct Mol Biol. 2016 Jan;23(1):37-44
pubmed: 26619264
Biochem Soc Trans. 2011 Oct;39(5):1169-78
pubmed: 21936784
Oncotarget. 2017 Apr 11;8(15):25469-25481
pubmed: 28424416
BMC Biol. 2014 Nov 11;12:94
pubmed: 25385277
Molecules. 2015 Feb 12;20(2):3027-49
pubmed: 25685910
Cytoskeleton (Hoboken). 2015 Apr;72(4):182-92
pubmed: 25809136
J Mol Biol. 2014 Jul 29;426(15):2886-99
pubmed: 24878061
Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):null
pubmed: 27527589
PLoS Biol. 2016 May 24;14(5):e1002464
pubmed: 27219477
Curr Opin Cell Biol. 2013 Aug;25(4):483-8
pubmed: 23510681
Gene. 2016 May 25;583(1):64-77
pubmed: 26945625
Biomed Res Int. 2014;2014:549719
pubmed: 25243149
Cell. 2016 Oct 6;167(2):512-524.e14
pubmed: 27667686
Cell. 2009 Sep 4;138(5):911-22
pubmed: 19737519
Front Mol Biosci. 2017 Aug 24;4:58
pubmed: 28884116
Cell. 2003 Feb 21;112(4):467-80
pubmed: 12600311
J Cell Biol. 2016 Dec 19;215(6):875-889
pubmed: 27903610
Nat Commun. 2014 Jul 31;5:4527
pubmed: 25078033
Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580
pubmed: 29271116
Mol Biochem Parasitol. 2017 Jun;214:75-81
pubmed: 28389272
Nat Chem Biol. 2013 Sep;9(9):548-56
pubmed: 23892893
Cancer Cell. 2015 Nov 9;28(5):653-665
pubmed: 26555175
Nat Chem Biol. 2015 Nov;11(11):818-21
pubmed: 26485069
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11976-81
pubmed: 23818610

Auteurs

Jonathan B Steinman (JB)

Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States.

Tarun M Kapoor (TM)

Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States. Electronic address: kapoor@rockefeller.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines AAA › Using chemical inhibitors to probe AAA protein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Using chemical inhibitors to probe AAA protein...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Using chemical inhibitors to probe AAA protein...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Using chemical inhibitors to probe AAA protein...
questionsmedicales.fr › Préparations pharmaceutiques › Using chemical inhibitors to probe AAA protein...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Using chemical inhibitors to probe AAA protein...