Clinical and neurodevelopmental features in children with cerebral palsy and probable congenital Zika.
Cerebral Palsy
/ complications
Developmental Disabilities
/ diagnosis
Female
Gestational Age
Humans
Infant
Infant, Newborn
Male
Microcephaly
/ complications
Neurodevelopmental Disorders
/ diagnosis
Neuroimaging
/ methods
Neurologic Examination
/ methods
Zika Virus
/ isolation & purification
Zika Virus Infection
/ diagnostic imaging
Cerebral palsy
Neurodevelopment
Zika virus
Journal
Brain & development
ISSN: 1872-7131
Titre abrégé: Brain Dev
Pays: Netherlands
ID NLM: 7909235
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
26
08
2018
revised:
29
12
2018
accepted:
13
03
2019
pubmed:
28
3
2019
medline:
7
1
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
To describe the neurological and neurodevelopmental features at 1 year of age in children with cerebral palsy (CP) related to probable congenital Zika (CZ), followed in a referral neurorehabilitation hospital. Data on 82 children with CP associated with probable CZ, who consecutively attended the neurodevelopmental and neurological assessment around one year of age, were collected. For neurodevelopmental evaluation, Bayley-III Scales of Infant and Toddler Development was used. Descriptive statistical analysis was performed. The children were admitted into the rehabilitation program at a young age (mean age: 4.8 months, SD 3.1), followed beyond the first year of life (mean age of follow up: 13.2 months, SD 2.1), born to young mothers (mean age: 28.1 years, SD 5.9), in their first pregnancy (62.2%). The majority had severe congenital microcephaly (62.0%), spastic CP (96.3%), epilepsy (63.4%), absent expected postural reactions (93.2%), abnormal persistence of primitive reflexes (94.7%), and severe neuroimaging abnormalities, predominantly calcifications (97.6%). Extremely low performances on cognitive (95.1%), language (97.6%) and motor (97.6%) developmental composite scores were observed. There was a correlation between the cognitive score with the birth head circumference (HC) (r = 0.3, p = 0.01) and with the follow up HC (r = 0.4, p < 0.01), as well as between the follow up HC with the motor score (r = 0.2, p = 0.03). Congenital Zika may be associated with a severe form of CP, mainly bilateral spastic, with a severe global neurodevelopmental impairment and early signs of a poor prognosis for independent walking. Head circumference may be a prognostic marker among those children. These results may help establish goals for the rehabilitation program and identify priority health services.
Identifiants
pubmed: 30914212
pii: S0387-7604(18)30433-9
doi: 10.1016/j.braindev.2019.03.005
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
587-594Informations de copyright
Copyright © 2019 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.