The ossification status of Wistar rat fetuses at the end of gestation.
Fetal skeleton
Individual data
Ossification
Wistar rat
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
28
01
2019
revised:
18
03
2019
accepted:
22
03
2019
pubmed:
28
3
2019
medline:
13
3
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
We present a comprehensive description of spontaneous skeletal development of Wistar rat fetuses close to parturition. Fetuses were collected on the day of expected parturition and one and two days before (Gestation Days 21-23) and skeletal development state was examined. Data is presented on an individual fetal basis to allow insights in developmental patterns. The distal parts of the limbs and the cervical and caudal vertebral column were identified as areas of the greatest developmental difference in the examined time frame. Extensive knowledge of the ossification process in individual fetuses allows a better resolution of deviations from normal and gives valuable information for the grading of delayed maturation and structural deviations. The data base is helpful to overcome the bottleneck of coincident occurrence of low incidences of skeletal abnormalities in the dose groups and the control group complicating risk assessment of test articles.
Identifiants
pubmed: 30914303
pii: S0890-6238(19)30022-X
doi: 10.1016/j.reprotox.2019.03.005
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-49Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.