n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial.
Aged
Antioxidants
/ metabolism
Aortic Aneurysm, Abdominal
/ drug therapy
Erythrocytes
/ drug effects
Fatty Acid Elongases
/ metabolism
Fatty Acids
/ metabolism
Fatty Acids, Omega-3
/ pharmacology
Fatty Acids, Unsaturated
/ metabolism
Female
Gas Chromatography-Mass Spectrometry
Humans
Linoleic Acid
/ metabolism
Lipid Metabolism
/ drug effects
Male
Middle Aged
abdominal aortic aneurysms
antioxidants
clinical studies
diet and dietary lipids
diet effects/lipid metabolism
omega-3 fatty acids
omega-3 index
polyunsaturated fatty acids
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
04
02
2019
revised:
06
03
2019
pubmed:
28
3
2019
medline:
14
7
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0-4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 PUFA (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12 week randomized placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid (LA), and AAA and increased Δ6-desaturase activity and biosynthesis of arachidonic acid (AA) from LA. Omega-3 PUFA supplementation (1.5 g DHA + 0.3 g EPA/day) decreased red blood cell distribution width (14.8 ± 0.4% to 13.8 ± 0.2%;
Identifiants
pubmed: 30914500
pii: S0022-2275(20)32255-0
doi: 10.1194/jlr.P093013
pmc: PMC6547637
doi:
Substances chimiques
Antioxidants
0
Fatty Acids
0
Fatty Acids, Omega-3
0
Fatty Acids, Unsaturated
0
Linoleic Acid
9KJL21T0QJ
Fatty Acid Elongases
EC 2.3.1.-
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1154-1163Informations de copyright
Copyright © 2019 Meital et al.
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