Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.
Actin Cytoskeleton
/ metabolism
B-Lymphocytes
/ immunology
Cells, Cultured
Extracellular Vesicles
/ metabolism
Gene Expression Profiling
Humans
Immunomodulation
/ immunology
Mesenchymal Stem Cells
/ metabolism
MicroRNAs
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Proteome
/ genetics
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ physiology
B cells
PI3K-AKT signaling pathway
actin cytoskeleton
extracellular vesicles
high-throughput analysis
mesenchymal stromal cells
miRNA-155-5p
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
11
2018
accepted:
19
02
2019
entrez:
28
3
2019
pubmed:
28
3
2019
medline:
8
9
2020
Statut:
epublish
Résumé
Mesenchymal stromal cells (MSCs) are adult, multipotent cells of mesodermal origin representing the progenitors of all stromal tissues. MSCs possess significant and broad immunomodulatory functions affecting both adaptive and innate immune responses once MSCs are primed by the inflammatory microenvironment. Recently, the role of extracellular vesicles (EVs) in mediating the therapeutic effects of MSCs has been recognized. Nevertheless, the molecular mechanisms responsible for the immunomodulatory properties of MSC-derived EVs (MSC-EVs) are still poorly characterized. Therefore, we carried out a molecular characterization of MSC-EV content by high-throughput approaches. We analyzed miRNA and protein expression profile in cellular and vesicular compartments both in normal and inflammatory conditions. We found several proteins and miRNAs involved in immunological processes, such as MOES, LG3BP, PTX3, and S10A6 proteins, miR-155-5p, and miR-497-5p. Different
Identifiants
pubmed: 30915084
doi: 10.3389/fimmu.2019.00446
pmc: PMC6423067
doi:
Substances chimiques
MIRN155 microRNA, human
0
MIRN497 microRNA, human
0
MicroRNAs
0
Proteome
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
446Références
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Blood. 2001 Oct 15;98(8):2396-402
pubmed: 11588036
Circulation. 2002 Jan 1;105(1):93-8
pubmed: 11772882
Nat Rev Immunol. 2002 Aug;2(8):569-79
pubmed: 12154376
Dis Colon Rectum. 2005 Jul;48(7):1416-23
pubmed: 15933795
Stem Cells. 2006 Feb;24(2):386-98
pubmed: 16123384
Osteoarthritis Cartilage. 2005 Oct;13(10):845-53
pubmed: 16129630
Leukemia. 2006 May;20(5):847-56
pubmed: 16453000
J Cell Sci. 2006 Jun 1;119(Pt 11):2204-13
pubmed: 16684817
Blood. 2007 Feb 15;109(4):1743-51
pubmed: 17062733
Am J Physiol Renal Physiol. 2007 May;292(5):F1626-35
pubmed: 17213465
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Anal Bioanal Chem. 2008 Mar;390(5):1327-42
pubmed: 18224487
BMC Cancer. 2008 Jan 28;8:25
pubmed: 18226209
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Gut. 2009 Jul;58(7):929-39
pubmed: 19136511
Trends Cell Biol. 2009 Feb;19(2):43-51
pubmed: 19144520
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
J Hepatol. 2009 Jun;50(6):1174-83
pubmed: 19398237
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
J Zhejiang Univ Sci B. 2009 Aug;10(8):619-24
pubmed: 19650201
J Immunol. 2009 Sep 15;183(6):3720-30
pubmed: 19692638
Br J Cancer. 2009 Oct 6;101(7):1145-54
pubmed: 19724273
Anal Bioanal Chem. 2010 May;397(1):25-41
pubmed: 20091299
J Periodontal Res. 2010 Oct;45(5):589-601
pubmed: 20546116
Infect Immun. 2010 Sep;78(9):3822-31
pubmed: 20605984
Immunol Rev. 2010 Sep;237(1):191-204
pubmed: 20727037
Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2):null
pubmed: 21047917
Tissue Eng Part A. 2011 May;17(9-10):1457-64
pubmed: 21247343
Mol Biosyst. 2011 Mar;7(3):677-86
pubmed: 21286649
Blood. 2011 Jul 14;118(2):380-9
pubmed: 21602525
Leukemia. 2011 Sep;25(9):1408-14
pubmed: 21617697
J Cell Sci. 2011 Aug 1;124(Pt 15):2611-21
pubmed: 21750189
Am J Cancer Res. 2011;1(1):98-110
pubmed: 21969178
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Cell Transplant. 2012;21(8):1697-709
pubmed: 22410280
Stem Cells Dev. 2012 Oct 10;21(15):2789-97
pubmed: 22533467
Blood Cancer J. 2012 May;2(5):e73
pubmed: 22829975
Food Chem. 2012 Dec 1;135(3):2052-69
pubmed: 22953957
Mayo Clin Proc. 2012 Sep;87(9):909-14
pubmed: 22958995
PLoS One. 2012;7(9):e44468
pubmed: 22970226
Nucleic Acids Res. 2013 Jan 7;41(1):542-53
pubmed: 23143100
Stem Cells Dev. 2013 Jun 15;22(12):1789-801
pubmed: 23339531
Biochem Soc Trans. 2013 Feb 1;41(1):245-51
pubmed: 23356291
J Cell Biol. 2013 Feb 18;200(4):373-83
pubmed: 23420871
Ann N Y Acad Sci. 2013 Mar;1280:24-6
pubmed: 23551098
Stem Cells Dev. 2013 Nov 15;22(22):2990-3002
pubmed: 23819720
Biochim Biophys Acta. 2014 Feb;1838(2):569-78
pubmed: 23886914
J Cell Sci. 2013 Dec 15;126(Pt 24):5553-65
pubmed: 24105262
Stem Cells Cloning. 2011 Nov 17;4:61-72
pubmed: 24198531
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
J Extracell Vesicles. 2013 Dec 10;2:null
pubmed: 24349659
Leukemia. 2014 Apr;28(4):970-3
pubmed: 24445866
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
Gene. 2014 Jul 25;545(2):282-9
pubmed: 24835311
Genome Biol. 2014;15(12):550
pubmed: 25516281
Crit Rev Immunol. 2015;35(1):15-31
pubmed: 25746045
Mol Ther. 2015 May;23(5):812-823
pubmed: 25868399
Arthritis Res Ther. 2015 Mar 31;17:88
pubmed: 25880839
Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6
pubmed: 25977294
Tumour Biol. 2015 Dec;36(12):9739-52
pubmed: 26156801
Int J Infect Dis. 2015 Nov;40:135-41
pubmed: 26433115
Transfus Med Rev. 2016 Jan;30(1):37-43
pubmed: 26689863
Stem Cell Res Ther. 2016 Feb 03;7:23
pubmed: 26841872
Tissue Eng Part B Rev. 2016 Aug;22(4):322-9
pubmed: 26861485
J Proteomics. 2016 Apr 14;138:106-14
pubmed: 26917472
Oncotarget. 2016 Apr 19;7(16):21713-27
pubmed: 26967055
Expert Rev Clin Immunol. 2016;12(5):501-7
pubmed: 26982005
J Cell Biochem. 2016 Nov;117(11):2559-69
pubmed: 27012556
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
Sci Rep. 2016 Apr 13;6:24120
pubmed: 27071676
J Exp Clin Cancer Res. 2016 Jun 27;35:103
pubmed: 27349385
Biochim Biophys Acta. 2016 Oct;1857(10):1651-60
pubmed: 27378191
Lancet. 2016 Sep 24;388(10051):1251-2
pubmed: 27477895
Cell Immunol. 2016 Dec;310:108-115
pubmed: 27576175
Front Cell Dev Biol. 2016 Aug 22;4:83
pubmed: 27597941
Glia. 2017 Jan;65(1):169-181
pubmed: 27758000
Trends Cell Biol. 2017 Mar;27(3):172-188
pubmed: 27979573
Free Radic Biol Med. 2016 Dec;101:305-316
pubmed: 27989750
Stem Cells Transl Med. 2017 Apr;6(4):1262-1272
pubmed: 28213967
PLoS One. 2017 Mar 20;12(3):e0173817
pubmed: 28319200
Leukemia. 2017 Jun;31(6):1259-1268
pubmed: 28321122
Stem Cells Int. 2017;2017:1758139
pubmed: 28377788
Leukemia. 2017 Sep;31(9):2009-2010
pubmed: 28656959
Stem Cell Investig. 2017 Sep 16;4:75
pubmed: 29057247
Sci Transl Med. 2017 Nov 15;9(416):null
pubmed: 29141887
Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737):null
pubmed: 29158311
Immunol Lett. 2018 Feb;194:4-12
pubmed: 29248489
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228
pubmed: 29339798
Stem Cells Int. 2018 May 27;2018:9863194
pubmed: 29977309
J Gen Microbiol. 1967 Oct;49(1):1-11
pubmed: 4168882
Exp Hematol. 1974;2(2):83-92
pubmed: 4455512
Eur J Biochem. 1998 Mar 15;252(3):339-46
pubmed: 9546647