Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through
Adolescent
Amino Acid Substitution
/ genetics
Autoantigens
/ chemistry
Bangladesh
/ epidemiology
Child
Child, Preschool
Computer Simulation
Congenital Hypothyroidism
/ epidemiology
Female
Genotype
Humans
Iodide Peroxidase
/ chemistry
Iron-Binding Proteins
/ chemistry
Male
Models, Molecular
Molecular Docking Simulation
Mutation
/ genetics
Phenotype
Structure-Activity Relationship
Thyroid Gland
/ metabolism
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
07
2018
revised:
03
01
2019
accepted:
10
01
2019
entrez:
28
3
2019
pubmed:
28
3
2019
medline:
25
7
2019
Statut:
epublish
Résumé
Although thyroid dyshormonogenesis (TDH) accounts for 10-20% of congenital hypothyroidism (CH), the molecular etiology of TDH is unknown in Bangladesh. Thyroid peroxidase (TPO) is most frequently associated with TDH and the present study investigated the spectrum of TPO mutations in Bangladeshi patients and analyzed the effects of mutations on TPO protein structure through
Identifiants
pubmed: 30915365
doi: 10.1155/2019/9218903
pmc: PMC6409061
doi:
Substances chimiques
Autoantigens
0
Iron-Binding Proteins
0
TPO protein, human
EC 1.11.1.7
Iodide Peroxidase
EC 1.11.1.8
Types de publication
Journal Article
Langues
eng
Pagination
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