Do-not-resuscitate status is correlated with the prescribed use of systemic strong opioid analgesics in patients with terminal cancer: an observational study.
Do-not-resuscitate
Pain
Systemic strong opioid analgesics
Terminal cancer
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
20
09
2018
accepted:
19
03
2019
pubmed:
28
3
2019
medline:
23
11
2019
entrez:
28
3
2019
Statut:
ppublish
Résumé
The purpose of this study is to determine the possible correlation between the do-not-resuscitate (DNR) status and the prescribed use of systemic strong opioid analgesics (SSOA) among patients with terminal cancer in Taiwan. This retrospective cross-sectional study used data from a single tertiary care medical center. We identified patients with terminal cancer who died after signing a DNR order between 2008 and 2016. Subsequently, we reviewed their clinical characteristics, DNR consent type, survival time after DNR declaration, and SSOA dose. Of the 4123 patients enrolled for this study, 1380 (33.5%) had received SSOA before DNR and 2742 (66.5%) had received SSOA after DNR (p < 0.001). SSOA doses administered after the DNR order were significantly higher than those administered before the DNR order (median, 78 vs. 60 mg, p < 0.01). Patients' DNR status likely influenced physician decision in prescribing SSOA. However, additional studies are necessary to clarify the factors that influence the decision-making of physicians regarding SSOA prescription.
Identifiants
pubmed: 30915568
doi: 10.1007/s00520-019-04765-6
pii: 10.1007/s00520-019-04765-6
doi:
Substances chimiques
Analgesics, Opioid
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
4507-4513Références
Cancer. 1999 Sep 1;86(5):871-7
pubmed: 10463988
Pain. 2007 Dec 5;132(3):312-20
pubmed: 17916403
Clin Interv Aging. 2008;3(2):273-8
pubmed: 18686750
Ann Oncol. 2007 Sep;18(9):1437-49
pubmed: 17355955
CMAJ. 2018 Apr 23;190(16):E500-E506
pubmed: 29685910
Lancet Oncol. 2003 May;4(5):312-8
pubmed: 12732169
Am J Geriatr Psychiatry. 2016 Apr;24(4):261-71
pubmed: 26976293
Health Qual Life Outcomes. 2004 Feb 12;2:8
pubmed: 14962348
Cancer Treat Rev. 2001 Jun;27(3):165-76
pubmed: 11417967
Curr Opin Support Palliat Care. 2013 Dec;7(4):424-30
pubmed: 24145680
J Clin Oncol. 2014 Jun 1;32(16):1647-54
pubmed: 24799469
Ann Oncol. 2012 Oct;23 Suppl 7:vii139-54
pubmed: 22997447
Am J Hosp Palliat Care. 1998 Jul-Aug;15(4):217-22
pubmed: 9729972
J Natl Cancer Inst Monogr. 2004;(32):103-4
pubmed: 15263049
J Pain Symptom Manage. 2001 Apr;21(4):282-9
pubmed: 11312042
Lancet. 2000 Jul 29;356(9227):398-9
pubmed: 10972375