Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.
Acetylation
Animals
Arousal
/ physiology
Calcium Channels
/ physiology
Central Nervous System Stimulants
/ therapeutic use
Decerebrate State
Deep Brain Stimulation
GABAergic Neurons
/ physiology
Gait
/ physiology
Gamma Rhythm
/ physiology
Gene Expression Regulation
Histones
/ metabolism
Humans
Modafinil
/ therapeutic use
Neurodegenerative Diseases
/ physiopathology
Parkinson Disease
/ physiopathology
Pedunculopontine Tegmental Nucleus
/ physiology
Protein Processing, Post-Translational
Sleep, REM
/ physiology
Transcription, Genetic
Wakefulness
/ physiology
N-type calcium channels
P/Q-type calcium channels
REM sleep
arousal
deep brain stimulation
electrical coupling
gamma activity
histone deacetylation
locomotion
pedunculopontine nucleus
waking
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
02
2019
accepted:
06
03
2019
pubmed:
28
3
2019
medline:
18
7
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the revelation of electrical coupling in the PPN and other arousal and sleep-wake control regions, the third was the determination of intrinsic gamma band oscillations in PPN neurons, and the last was the discovery of gene transcription resulting from the manifestation of gamma activity in the PPN. These discoveries have led to novel therapies such as PPN deep brain stimulation (DBS) for Parkinson's disease (PD), identified the mechanism of action of the stimulant modafinil, determined the presence of separate mechanisms underlying gamma activity during waking versus REM sleep, and revealed the presence of gene transcription during the manifestation of gamma band oscillations. These discoveries set the stage for additional major advances in the treatment of a number of disorders.
Identifiants
pubmed: 30916810
doi: 10.1002/jnr.24417
pmc: PMC6764922
mid: NIHMS1523349
doi:
Substances chimiques
Calcium Channels
0
Central Nervous System Stimulants
0
Histones
0
Modafinil
R3UK8X3U3D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1515-1520Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM110702
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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